MAIT cells promote tumor initiation, growth and metastases via tumor MR1.
Yan, Juming; Allen, Stacey; McDonald, Elizabeth; Das, Indrajit; Mak, Jeffrey Y W; Liu, Ligong; Fairlie, David P; Meehan, Bronwyn S; Chen, Zhenjun; Corbett, Alexandra J; Varelias, Antiopi; Smyth, Mark J; Teng, Michele W L
CANCER DISCOVERY - 1/12/2019
NH&MRC Research Fellowship - 1078671
IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling.
Wilkinson, Andrew N; Chang, Karshing; Kuns, Rachel D; Henden, Andrea S; Minnie, Simone A; Ensbey, Kathleen S; Clouston, Andrew D; Zhang, Ping; Koyama, Motoko; Hidalgo, Juan; Rose-John, Stefan; Varelias, Antiopi; Vuckovic, Slavica; Gartlan, Kate H; Hill, Geoffrey R
BLOOD - 1/10/2019
Pegylated interferon-2a invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation.
Henden, Andrea S; Varelias, Antiopi; Leach, Justine; Sturgeon, Elise; Avery, Judy; Kelly, Jessica; Olver, Stuart; Samson, Luke; Hartel, Gunter; Durrant, Simon; Butler, Jason; Morton, Anthony J; Misra, Ashish; Tey, Siok-Keen; Subramoniapillai, Elango; Curley, Cameron; Kennedy, Glen; Hill, Geoffrey R
BLOOD ADVANCES - 1/10/2019
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.
Koyama, Motoko; Mukhopadhyay, Pamela; Schuster, Iona S; Henden, Andrea S; Hülsdünker, Jan; Varelias, Antiopi; Vetizou, Marie; Kuns, Rachel D; Robb, Renee J; Zhang, Ping; Blazar, Bruce B; Thomas, Ranjeny; Begun, Jakob; Waddell, Nicola; Trinchieri, Giorgio; Zeiser, Robert; Clouston, Andrew D; Degli-Esposti, Mariapia A; Hill, Geoffrey R
IMMUNITY - 1/09/2019
NHLBI NIH HHS - R01 HL148164
PAG1 limits allergen-induced type 2 inflammation in the murine lung.
Ullah, Md Ashik; Vicente, Cristina T; Collinson, Natasha; Curren, Bodie; Sikder, Md Al Amin; Sebina, Ismail; Simpson, Jennifer; Varelias, Antiopi; Lindquist, Jonathan A; Ferreira, Manuel A R; Phipps, Simon
ALLERGY - 1/07/2019
Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology
Koyama, Motoko; Mukhopadhyay, Pamela; Schuster, Iona S.; Henden, Andrea S.; Hulsdunker, Jan; Varelias, Antiopi; Vetizou, Marie; Kuns, Rachel D.; Robb, Renee J.; Zhang, Ping; Blazar, Bruce R.; Thomas, Ranjeny; Begun, Jakob; Waddell, Nicola; Trinchieri, Giorgio; Zeiser, Robert; Clouston, Andrew D.; Degli-Esposti, Mariapia A.; Hill, Geoffrey R.
JOURNAL OF IMMUNOLOGY - 1/05/2019
Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.
Zhang, Ping; Raju, Jyothy; Ullah, Md Ashik; Au, Raymond; Varelias, Antiopi; Gartlan, Kate H; Olver, Stuart D; Samson, Luke D; Sturgeon, Elise; Zomerdijk, Nienke; Avery, Judy; Gargett, Tessa; Brown, Michael P; Coin, Lachlan J; Ganesamoorthy, Devika; Hutchins, Cheryl; Pratt, Gary R; Kennedy, Glen A; Morton, A James; Curley, Cameron I; Hill, Geoffrey R; Tey, Siok-Keen
CLINICAL CANCER RESEARCH - 1/02/2019
National Health and Medical Research Council (NHMRC, Australia) - APP1053135
Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation.
Martins, Jose Paulo; Andoniou, Christopher E; Fleming, Peter; Kuns, Rachel D; Schuster, Iona S; Voigt, Valentina; Daly, Sheridan; Varelias, Antiopi; Tey, Siok-Keen; Degli-Esposti, Mariapia A; Hill, Geoffrey R
Science (New York, N.Y.) - 1/01/2019
National Health and Medical Research Council of Australia (NHMRC) - 1119298
A critical role for donor-derived IL-22 in cutaneous chronic GVHD.
Gartlan, Kate H; Bommiasamy, Hemamalini; Paz, Katelyn; Wilkinson, Andrew N; Owen, Mary; Reichenbach, Dawn K; Banovic, Tatjana; Wehner, Kimberly; Buchanan, Faith; Varelias, Antiopi; Kuns, Rachel D; Chang, Karshing; Fedoriw, Yuri; Shea, Thomas; Coghill, James; Zaiken, Michael; Plank, Maximilian W; Foster, Paul S; Clouston, Andrew D; Blazar, Bruce R; Serody, Jonathan S; Hill, Geoffrey R
AMERICAN JOURNAL OF TRANSPLANTATION - 1/09/2017
NCI NIH HHS - P01 CA142106
Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.
Zhang, Ping; Lee, Jason S; Gartlan, Kate H; Schuster, Iona S; Comerford, Iain; Varelias, Antiopi; Ullah, Md Ashik; Vuckovic, Slavica; Koyama, Motoko; Kuns, Rachel D; Locke, Kelly R; Beckett, Kirrilee J; Olver, Stuart D; Samson, Luke D; Montes de Oca, Marcela; de Labastida Rivera, Fabian; Clouston, Andrew D; Belz, Gabrielle T; Blazar, Bruce R; MacDonald, Kelli P; McColl, Shaun R; Thomas, Ranjeny; Engwerda, Christian R; Degli-Esposti, Mariapia A; Kallies, Axel; Tey, Siok-Keen; Hill, Geoffrey R
Science immunology - 1/04/2017
NIAID NIH HHS - R01 AI034495
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi; Ormerod, Kate L.; Bunting, Mark D.; Koyama, Motoko; Gartlan, Kate H.; Kuns, Rachel D.; Lachner, Nancy; Locke, Kelly R.; Lim, Chun Y.; Henden, Andrea S.; Zhang, Ping; Clouston, Andrew D.; Hasnain, Sumaira Z.; McGuckin, Michael A.; Blazar, Bruce R.; MacDonald, Kelli P. A.; Hugenholtz, Philip; Hill, Geoffrey R.
BLOOD - 1/04/2017
Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
Gartlan, Kate H.; Varelias, Antiopi; Koyama, Motoko; Robb, Renee J.; Markey, Kate A.; Chang, Karshing; Wilkinson, Andrew N.; Smith, David; Ullah, Md Ashik; Kuns, Rachel D.; Raffelt, Neil C.; Olver, Stuart D.; Lineburg, Katie E.; Teal, Bianca E.; Cheong, Melody; Teng, Michele W. L.; Smyth, Mark J.; Tey, Siok-Keen; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD ADVANCES - 1/02/2017
GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity
Bunting, Mark D.; Varelias, Antiopi; Souza-Fonseca-Guimaraes, Fernando; Schuster, Iona S.; Lineburg, Katie E.; Kuns, Rachel D.; Fleming, Peter; Locke, Kelly R.; Huntington, Nicholas D.; Blazar, Bruce R.; Lane, Steven W.; Tey, Siok-Keen; MacDonald, Kelli P. A.; Smyth, Mark J.; Degli-Esposti, Mariapia A.; Hill, Geoffrey R.
BLOOD - 1/02/2017
IL-17A-Producing gammadelta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver
Sheel, Meru; Beattie, L; Frame, Teija C. M.; Rivera, Fabian de Labastida; Faleiro, Rebecca; Bunn, Patrick T.; de Oca, Marcela Montes; Edwards, Chelsea L.; Ng, Susanna S.; Kumar, Rajiv; Amante, FH; Best, Shannon E.; McColl, Shaun R.; Varelias, Antiopi; Kuns, Rachel; MacDonald, Kelli P. A.; Smyth, Mark J.; Haque, Ashraful; Hill, Geoffrey R.; Engwerda, C
JOURNAL OF IMMUNOLOGY - 1/12/2015
Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation
Ullah, Ashik; Revez, Joana A.; Loh, Zhixuan; Simpson, Jennifer; Zhang, Vivian; Bain, L.; Varelias, Antiopi; Rose-John, Stefan; Blumenthal, Antje; Smyth, M. J.; Hill, Geoffrey R.; Sukkar, Maria B.; Ferreira, Manuel A. R.; Phipps, Simon
The Journal of allergy and clinical immunology - 1/10/2015
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
Gartlan, Kate H.; Markey, Kate A.; Varelias, Antiopi; Bunting, Mark D.; Koyama, Motoko; Kuns, Rachel; Raffelt, Neil C.; Olver, Stuart; Lineburg, Katie E.; Cheong, Melody; Teal, Bianca E.; Lor, Mary; Comerford, Iain; Teng, Michele W. L.; Smyth, Mark J.; McCluskey, James; Rossjohn, Jamie; Stockinger, Brigitta; Boyle, GM; Lane, Steven W.; Clouston, AD; McColl, Shaun R.; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD - 1/09/2015
Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease
Koyama, Motoko; Cheong, Melody; Markey, Kate A.; Gartlan, Kate H.; Kuns, Rachel; Locke, Kelly R.; Lineburg, Katie E.; Teal, Bianca E.; Leveque-El Mouttie, Lucie; Bunting, Mark D.; Vuckovic, Slavica; Zhang, Ping; Teng, Michele W. L.; Varelias, Antiopi; Tey, Siok-Keen; Wockner, Leesa; Engwerda, C; Smyth, Mark J.; Belz, Gabrielle T.; McColl, Shaun R.; MacDonald, Kelli P. A.; Hill, Geoffrey R.
JOURNAL OF EXPERIMENTAL MEDICINE - 1/07/2015
Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation
Varelias, Antiopi; Gartlan, Kate H.; Kreijveld, Ellen; Olver, Stuart; Lor, Mary; Kuns, Rachel; Lineburg, Katie E.; Teal, Bianca E.; Raffelt, Neil C.; Cheong, Melody; Alexander, Kylie A.; Koyama, Motoko; Markey, Kate A.; Sturgeon, Elise; Leach, Justine; Reddy, Pavan; Kennedy, G; Yanik, Gregory; Blazar, Bruce R.; Tey, Siok-Keen; Clouston, AD; MacDonald, Kelli P. A.; Cooke, Kenneth R.; Hill, Geoffrey R.
BLOOD - 1/04/2015
