Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors.
Gartlan, Kate H; Jaiswal, Jagdish K; Bull, Matthew R; Akhlaghi, Hedieh; Sutton, Vivien R; Alexander, Kylie A; Chang, Karshing; Hill, Geoffrey R; Miller, Christian K; O'Connor, Patrick D; Jose, Jiney; Trapani, Joseph A; Charman, Susan A; Spicer, Julie A; Jamieson, Stephen M F
ACS pharmacology & translational science - 1/01/2022
A Phase 3 Double-Blind Study of the Addition of Tocilizumab versus Placebo to Cyclosporin/Methotrexate GvHD Prophylaxis.
Kennedy, Glen; Tey, Siok-Keen; Buizen, Luke; Varelias, Antiopi; Gartlan, Kate H; Curley, Cameron; Olver, Stuart; Chang, Karshing; Butler, Jason; Misra, Ashish; Subramoniapillai, Elango; Morton, Anthony; Durrant, Simon; Henden, Andrea S; Moore, John; Ritchie, David S; Gottlieb, David; Cooney, Julian P; Paul, Sanjoy K; Hill, Geoffrey R
BLOOD - 1/01/2021
IFN? Therapy Prevents Severe Gastrointestinal Graft-versus-Host Disease.
Henden, Andrea S; Koyama, Motoko; Robb, Renee J; Forero, Adriana; Kuns, Rachel D; Chang, Karshing; Ensbey, Kathleen S; Varelias, Antiopi; Kazakoff, Stephen H; Waddell, Nicola; Clouston, Andrew D; Giri, Rabina; Begun, Jakob; Blazar, Bruce R; Degli-Esposti, Mariapia A; Kotenko, Sergei V; Lane, Steven W; Bowerman, Kate; Savan, Ram; Hugenholtz, Philip; Gartlan, Kate H; Hill, Geoffrey R
BLOOD - 1/01/2021
Phase II trial of single-agent panobinostat consolidation improves responses after sub-optimal transplant outcomes in multiple myeloma.
Mithraprabhu, Sridurga; Kalff, Anna; Gartlan, Kate H; Savvidou, Ioanna; Khong, Tiffany; Ramachandran, Malarmathy; Cooke, Rachel E; Bowen, Kathryn; Hill, Geoffrey R; Reynolds, John; Spencer, Andrew
BRITISH JOURNAL OF HAEMATOLOGY - 1/09/2020
NCI NIH HHS - U01 CA244291
ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome.
Cheong, Melody; Gartlan, Kate H; Lee, Jason S; Tey, Siok-Keen; Zhang, Ping; Kuns, Rachel D; Andoniou, Christopher E; Martins, Jose Paulo; Chang, Karshing; Sutton, Vivien R; Kelly, Greg; Varelias, Antiopi; Vuckovic, Slavica; Markey, Kate A; Boyle, Glen M; Smyth, Mark J; Engwerda, Christian R; MacDonald, Kelli P A; Trapani, Joseph A; Degli-Esposti, Mariapia A; Koyama, Motoko; Hill, Geoffrey R
Cancer Immunology Research - 1/05/2020
Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation
Gartlan, Kate H.; Wilkinson, Andrew; Chang, Karshing; Kuns, Rachel D.; Henden, Andrea; Minnie, Simone A.; Ensbey, Kathleen S.; Clouston, Andrew; Zhang, Ping; Koyama, Motoko; Hidalgo, Juan; Rose-John, Stefan; Varelias, Antiopi; Vuckovic, Slavica; Hill, Geoffrey R.
JOURNAL OF IMMUNOLOGY - 1/05/2020
IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling.
Wilkinson, Andrew N; Chang, Karshing; Kuns, Rachel D; Henden, Andrea S; Minnie, Simone A; Ensbey, Kathleen S; Clouston, Andrew D; Zhang, Ping; Koyama, Motoko; Hidalgo, Juan; Rose-John, Stefan; Varelias, Antiopi; Vuckovic, Slavica; Gartlan, Kate H; Hill, Geoffrey R
BLOOD - 1/10/2019
Donor T-cell-derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract.
Gartlan, Kate H; Koyama, Motoko; Lineburg, Katie E; Chang, Karshing; Ensbey, Kathleen S; Kuns, Rachel D; Henden, Andrea S; Samson, Luke D; Clouston, Andrew D; Lopez, Angel F; MacDonald, Kelli P A; Hill, Geoffrey R
BLOOD ADVANCES - 1/10/2019
Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.
Spicer, Julie A; Miller, Christian K; O'Connor, Patrick D; Jose, Jiney; Giddens, Anna C; Jaiswal, Jagdish K; Jamieson, Stephen M F; Bull, Matthew R; Denny, William A; Akhlaghi, Hedieh; Trapani, Joseph A; Hill, Geoff R; Chang, Karshing; Gartlan, Kate H
JOURNAL OF MEDICINAL CHEMISTRY - 1/09/2019
Wellcome Trust - 092717
Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.
Zhang, Ping; Raju, Jyothy; Ullah, Md Ashik; Au, Raymond; Varelias, Antiopi; Gartlan, Kate H; Olver, Stuart D; Samson, Luke D; Sturgeon, Elise; Zomerdijk, Nienke; Avery, Judy; Gargett, Tessa; Brown, Michael P; Coin, Lachlan J; Ganesamoorthy, Devika; Hutchins, Cheryl; Pratt, Gary R; Kennedy, Glen A; Morton, A James; Curley, Cameron I; Hill, Geoffrey R; Tey, Siok-Keen
CLINICAL CANCER RESEARCH - 1/02/2019
National Health and Medical Research Council (NHMRC, Australia) - APP1053135
Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo.
Khoury, David S; Cromer, Deborah; Elliott, Trish; Soon, Megan S F; Thomas, Bryce S; James, Kylie R; Best, Shannon E; Aogo, Rosemary A; Engel, Jessica A; Gartlan, Kate H; Akter, Jasmin; Sebina, Ismail; Haque, Ashraful; Davenport, Miles P
INTERNATIONAL JOURNAL FOR PARASITOLOGY - 1/12/2017
Australian Research Council - DP120100064
A critical role for donor-derived IL-22 in cutaneous chronic GVHD.
Gartlan, Kate H.; Bommiasamy, Hemamalini; Paz, Katelyn; Wilkinson, Andrew; Owen, Mary; Reichenbach, Dawn; Banovic, Tatjana; Wehner, Kimberly; Buchanan, Faith; Varelias, Antiopi; Kuns, Rachel; Chang, Karshing; Fedoriw, Yuri; Shea, Thomas C.; Coghill, James M., Jr.; Zaiken, Michael; Plank, Maximilian; Foster, Paul; Clouston, Andrew; Blazar, Bruce; Serody, Jonathan S.; Hill, Geoffrey R.
AMERICAN JOURNAL OF TRANSPLANTATION - 1/09/2017
NCI NIH HHS - P01 CA142106
An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
Forcade, Edouard; Paz, Katelyn; Flynn, Ryan; Griesenauer, Brad; Amet, Tohti; Li, Wei; Liu, Liangyi; Bakoyannis, Giorgos; Jiang, Di; Chu, Hong Wei; Lobera, Mercedes; Yang, Jianfei; Wilkes, David S.; Du, Jing; Gartlan, Kate; Hill, Geoffrey R.; MacDonald, Kelli P. A.; Espada, Eduardo L.; Blanco, Patrick; Serody, Jonathan S.; Koreth, John; Cutler, Corey S.; Antin, Joseph H.; Soiffer, Robert J.; Ritz, Jerome; Paczesny, Sophie; Blazar, Bruce R.
JCI INSIGHT - 1/06/2017
NIH - R01 CA168814
Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.
Zhang, Ping; Lee, Jason S; Gartlan, Kate H; Schuster, Iona S; Comerford, Iain; Varelias, Antiopi; Ullah, Md Ashik; Vuckovic, Slavica; Koyama, Motoko; Kuns, Rachel D; Locke, Kelly R; Beckett, Kirrilee J; Olver, Stuart D; Samson, Luke D; Montes de Oca, Marcela; de Labastida Rivera, Fabian; Clouston, Andrew D; Belz, Gabrielle T; Blazar, Bruce R; MacDonald, Kelli P; McColl, Shaun R; Thomas, Ranjeny; Engwerda, Christian R; Degli-Esposti, Mariapia A; Kallies, Axel; Tey, Siok-Keen; Hill, Geoffrey R
Science immunology - 1/04/2017
NIAID NIH HHS - R01 AI034495
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi; Ormerod, Kate L.; Bunting, Mark D.; Koyama, Motoko; Gartlan, Kate H.; Kuns, Rachel D.; Lachner, Nancy; Locke, Kelly R.; Lim, Chun Y.; Henden, Andrea S.; Zhang, Ping; Clouston, Andrew D.; Hasnain, Sumaira Z.; McGuckin, Michael A.; Blazar, Bruce R.; MacDonald, Kelli P. A.; Hugenholtz, Philip; Hill, Geoff R.
BLOOD - 1/04/2017
Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
Gartlan, Kate H.; Varelias, Antiopi; Koyama, Motoko; Robb, Renee J.; Markey, Kate A.; Chang, Karshing; Wilkinson, Andrew N.; Smith, David; Ullah, Md Ashik; Kuns, Rachel D.; Raffelt, Neil C.; Olver, Stuart D.; Lineburg, Katie E.; Teal, Bianca E.; Cheong, Melody; Teng, Michele W. L.; Smyth, Mark J.; Tey, Siok-Keen; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD ADVANCES - 1/02/2017
