BACKGROUND: Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome arrays and genotype imputation can now efficiently genotype rare nonsynonymous and loss of function variants. Such variants are expected to have deleterious functional consequences and to contribute to disease risk.
| Authors | Brazel, David M.; Jiang, Yu; Hughey, Jordan M.; Turcot, Valerie; Zhan, Xiaowei; Gong, Jian; Batini, Chiara; Weissenkampen, J. Dylan; Liu, MengZhen; Barnes, Daniel R.; Bertelsen, Sarah; Chou, Yi-Ling; Erzurumluoglu, A. Mesut; Faul, Jessica D.; Haessler, Jeff; Hammerschlag, Anke R.; Hsu, Chris; Kapoor, Manav; Lai, Dongbing; Le, Nhung; de Leeuw, Christiaan A.; Loukola, Anu; Mangino, Massimo; Melbourne, Carl A.; Pistis, Giorgio; Qaiser, Beenish; Rohde, Rebecca; Shao, Yaming; Stringham, Heather; Wetherill, Leah; Zhao, Wei; Agrawal, Arpana; Bierut, Laura; Chen, Chu; Eaton, Charles B.; Goate, Alison; Haiman, Christopher; Heath, Andrew; Iacono, William G.; Martin, Nicholas G.; Polderman, Tinca J.; Reiner, Alex; Rice, John; Schlessinger, David; Scholte, H. Steven; Smith, Jennifer A.; Tardif, Jean-Claude; Tindle, Hilary A.; van der Leij, Andries R.; Boehnke, Michael; Chang-Claude, Jenny; Cucca, Francesco; David, Sean P.; Foroud, Tatiana; Howson, Joanna M. M.; Kardia, Sharon L. R.; Kooperberg, Charles; Laakso, Markku; Lettre, Guillaume; Madden, Pamela; Mcgue, Matt; North, Kari; Posthuma, Danielle; Spector, Timothy; Stram, Daniel; Tobin, Martin D.; Weir, David R.; Kaprio, Jaakko; Abecasis, Goncalo R.; Liu, Dajiang J.; Vrieze, Scott; Surendran, Praveen; Young, Robin; Barnes, Daniel R.; Nielsen, Sune Fallgaard; Rasheed, Asif; Samuel, Maria; Zhao, Wei; Kontto, Jukka; Perola, Markus; Caslake, Muriel; de Craen, Anton J. M.; Trompet, Stella; Uria-Nickelsen, Maria; Malarstig, Anders; Reily, Dermot F.; Hoek, Maarten; Vogt, Thomas; Jukema, J. Wouter; Sattar, Naveed; Ford, Ian; Packard, Chris J.; Alam, Dewan S.; Majumder, Abdulla al Shafi; Di Ange-Lantonio, Emanuele; Chowdhury, Rajiv; Amouyel, Philippe; Arveiler, Dominique; Blankenberg, Stefan; Ferrieres, Jean; Kee, Frank; Kuulasmaa, Kari; Mueller-Nurasyid, Martina; Veronesi, Giovanni; Virtamo, Jarmo; Frossard, Philippe; Nordestgaard, Borge Gronne; Saleheen, Danish; Danesh, John; Butterworth, Adam S.; Howson, Joanna M. M.; Erzurumluoglu, A. Mesut; Jackson, Victoria E.; Melbourne, Carl A.; Varga, Tibor V.; Warren, Helen R.; Tragante, Vinicius; Tachmazidou, Ioanna; Harris, Sarah E.; Evangelou, Evangelos; Marten, Jonathan; Zhang, Weihua; Altmaier, Elisabeth; Luan, Jian'an; Langenberg, Claudia; Scott, Robert A.; Yaghootkar, Hanieh; Stirrups, Kathleen; Kanoni, Stavroula; Marouli, Eirini; Karpe, Fredrik; Dominiczak, Anna F.; Sever, Peter; Poulter, Neil; Rolandsson, Olov; Baumbach, Clemens; Afaq, Saima; Chambers, John C.; Kooner, Jaspal S.; Wareham, Nicholas J.; Renstrom, Frida; Hallmans, Goran; Marioni, Riccardo E.; Corley, Janie; Starr, John M.; Verweij, Niek; de Boer, Rudolf A.; van der Meer, Peter; Yavas, Ersin; Vaartjes, Ilonca; Bots, Michiel L.; Asselbergs, Folkert W.; Grabe, Hans J.; Volzke, Henry; Nauck, Matthias; Weiss, Stefan; Pharoah, Paul D. P.; Dunning, Alison M.; Dennis, Joe G.; Thompson, Deborah J.; Michailidou, Kyriaki; Easton, Douglas F.; Antoniou, Antonis C.; Tyrrell, Jessica; Mihailov, Evelin; Samani, Nilesh J.; Zhou, Kaixin; Neville, Matthew J.; Metspalu, Andres; Palmer, Colin N. A.; Hall, Ian P.; Strachan, David P.; Deary, Ian J.; Frayling, Tim M.; Hayward, Caroline; van der Harst, Pim; Zeggini, Eleftheria; Munroe, Patricia B.; Jansson, Jan-Hakan; Franks, Paul W.; Deloukas, Panos; Caulfield, Mark J.; Wain, Louise V.; Tobin, Martin D. |
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| Journal | BIOLOGICAL PSYCHIATRY |
| Pages | 946-955 |
| Volume | 85 |
| Date | 1/06/2019 |
| Grant ID | |
| Funding Body | National Institute on Drug Abuse |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.biopsych.2018.11.024 |
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