Pharmacodynamics of Pre-Operative PD1 checkpoint blockade and receptor activator of NFkB ligand (RANKL) inhibition in non-small cell lung cancer (NSCLC): study protocol for a multicentre, open-label, phase 1B/2, translational trial (POPCORN).
Ahern, Elizabeth; Cubitt, Annette; Ballard, Emma; Teng, Michele W L; Dougall, William C; Smyth, Mark J; Godbolt, David; Naidoo, Rishendran; Goldrick, Amanda; Hughes, Brett G M
Trials - 1/12/2019
Resistance to immunotherapy is associated with high parenchymal PD1+CD8+/CD8+T cells (PD1tR) driven by tumour CD155
de Oliveira, A. Lepletier; Madore, J.; O'donnell, S.; Johnston, R. L.; Eastgate, M.; Mallardo, D.; Ascierto, P. A.; Massi, D.; Merelli, B.; Mandala, M.; Wilmott, J. S.; Bald, T.; Stagg, J.; Routy, B.; Long, G. V.; Scolyer, R. A.; Waddell, N.; Dougall, W. C.; Teng, M. W. L.; Smyth, M.
ANNALS OF ONCOLOGY - 1/12/2019
MAIT cells promote tumor initiation, growth and metastases via tumor MR1.
Yan, Juming; Allen, Stacey; McDonald, Elizabeth; Das, Indrajit; Mak, Jeffrey Y W; Liu, Ligong; Fairlie, David P; Meehan, Bronwyn S; Chen, Zhenjun; Corbett, Alexandra J; Varelias, Antiopi; Smyth, Mark J; Teng, Michele W L
CANCER DISCOVERY - 1/12/2019
NH&MRC Research Fellowship - 1078671
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.
Li, Xian-Yang; Moesta, Achim K; Xiao, Christos; Nakamura, Kyohei; Casey, Mika; Zhang, Haiyan; Madore, Jason; Lepletier, Ailin; Aguilera, Amelia Roman; Sundarrajan, Ashmitha; Jacoberger-Foissac, Celia; Wong, Clifford; Dela Cruz, Tracy; Welch, Megan; Lerner, Alana G; Spatola, Bradley N; Soros, Vanessa B; Corbin, John; Anderson, Ana C; Effern, Maike; Hölzel, Michael; Robson, Simon C; Johnston, Rebecca L; Waddell, Nicola; Smith, Corey; Bald, Tobias; Geetha, Nishamol; Beers, Courtney; Teng, Michele W L; Smyth, Mark J
CANCER DISCOVERY - 1/11/2019
NCI NIH HHS - R21 CA221702