Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2.
Kaiserman, Dion; Zhao, Peishen; Rowe, Caitlin Lorraine; Leong, Andrea; Barlow, Nicholas; Joeckel, Lars Thomas; Hitchen, Corinne; Stewart, Sarah Elizabeth; Hollenberg, Morley D; Bunnett, Nigel; Suhrbier, Andreas; Bird, Phillip Ian
PLOS ONE - 1/01/2022
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond, Scott E; Mycroft-West, Courtney J; Gandhi, Neha S; Tree, Julia A; Le, Thuy T; Spalluto, C Mirella; Humbert, Maria V; Buttigieg, Karen R; Coombes, Naomi; Elmore, Michael J; Wand, Matthew; Nyström, Kristina; Said, Joanna; Setoh, Yin Xiang; Amarilla, Alberto A; Modhiran, Naphak; Sng, Julian D J; Chhabra, Mohit; Young, Paul R; Rawle, Daniel J; Lima, Marcelo A; Yates, Edwin A; Karlsson, Richard; Miller, Rebecca L; Chen, Yen-Hsi; Bagdonaite, Ieva; Yang, Zhang; Stewart, James; Nguyen, Dung; Laidlaw, Stephen; Hammond, Edward; Dredge, Keith; Wilkinson, Tom M A; Watterson, Daniel; Khromykh, Alexander A; Suhrbier, Andreas; Carroll, Miles W; Trybala, Edward; Bergström, Tomas; Ferro, Vito; Skidmore, Mark A; Turnbull, Jeremy E
ACS Central Science - 1/01/2022
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses.
Amarilla, Alberto A; Sng, Julian D J; Parry, Rhys; Deerain, Joshua M; Potter, James R; Setoh, Yin Xiang; Rawle, Daniel J; Le, Thuy T; Modhiran, Naphak; Wang, Xiaohui; Peng, Nias Y G; Torres, Francisco J; Pyke, Alyssa; Harrison, Jessica J; Freney, Morgan E; Liang, Benjamin; McMillan, Christopher L D; Cheung, Stacey T M; Guevara, Darwin J Da Costa; Hardy, Joshua M; Bettington, Mark; Muller, David A; Coulibaly, Fasséli; Moore, Frederick; Hall, Roy A; Young, Paul R; Mackenzie, Jason M; Hobson-Peters, Jody; Suhrbier, Andreas; Watterson, Daniel; Khromykh, Alexander A
Nature Communications - 1/01/2021