Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation.
Martins, Jose Paulo; Andoniou, Christopher E; Fleming, Peter; Kuns, Rachel D; Schuster, Iona S; Voigt, Valentina; Daly, Sheridan; Varelias, Antiopi; Tey, Siok-Keen; Degli-Esposti, Mariapia A; Hill, Geoffrey R
Science (New York, N.Y.) - 1/01/2019
National Health and Medical Research Council of Australia (NHMRC) - 1119298
A critical role for donor-derived IL-22 in cutaneous chronic GVHD.
Gartlan, Kate H.; Bommiasamy, Hemamalini; Paz, Katelyn; Wilkinson, Andrew; Owen, Mary; Reichenbach, Dawn; Banovic, Tatjana; Wehner, Kimberly; Buchanan, Faith; Varelias, Antiopi; Kuns, Rachel; Chang, Karshing; Fedoriw, Yuri; Shea, Thomas C.; Coghill, James M., Jr.; Zaiken, Michael; Plank, Maximilian; Foster, Paul; Clouston, Andrew; Blazar, Bruce; Serody, Jonathan S.; Hill, Geoffrey R.
AMERICAN JOURNAL OF TRANSPLANTATION - 1/09/2017
NCI NIH HHS - P01 CA142106
Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.
Zhang, Ping; Lee, Jason S; Gartlan, Kate H; Schuster, Iona S; Comerford, Iain; Varelias, Antiopi; Ullah, Md Ashik; Vuckovic, Slavica; Koyama, Motoko; Kuns, Rachel D; Locke, Kelly R; Beckett, Kirrilee J; Olver, Stuart D; Samson, Luke D; Montes de Oca, Marcela; de Labastida Rivera, Fabian; Clouston, Andrew D; Belz, Gabrielle T; Blazar, Bruce R; MacDonald, Kelli P; McColl, Shaun R; Thomas, Ranjeny; Engwerda, Christian R; Degli-Esposti, Mariapia A; Kallies, Axel; Tey, Siok-Keen; Hill, Geoffrey R
Science immunology - 1/04/2017
NIAID NIH HHS - R01 AI034495
Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome
Varelias, Antiopi; Ormerod, Kate L.; Bunting, Mark D.; Koyama, Motoko; Gartlan, Kate H.; Kuns, Rachel D.; Lachner, Nancy; Locke, Kelly R.; Lim, Chun Y.; Henden, Andrea S.; Zhang, Ping; Clouston, Andrew D.; Hasnain, Sumaira Z.; McGuckin, Michael A.; Blazar, Bruce R.; MacDonald, Kelli P. A.; Hugenholtz, Philip; Hill, Geoff R.
BLOOD - 1/04/2017
Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
Gartlan, Kate H.; Varelias, Antiopi; Koyama, Motoko; Robb, Renee J.; Markey, Kate A.; Chang, Karshing; Wilkinson, Andrew N.; Smith, David; Ullah, Md Ashik; Kuns, Rachel D.; Raffelt, Neil C.; Olver, Stuart D.; Lineburg, Katie E.; Teal, Bianca E.; Cheong, Melody; Teng, Michele W. L.; Smyth, Mark J.; Tey, Siok-Keen; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD ADVANCES - 1/02/2017
GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity
Bunting, Mark D.; Varelias, Antiopi; Souza-Fonseca-Guimaraes, Fernando; Schuster, Iona S.; Lineburg, Katie E.; Kuns, Rachel D.; Fleming, Peter; Locke, Kelly R.; Huntington, Nicholas D.; Blazar, Bruce R.; Lane, Steven W.; Tey, Siok-Keen; MacDonald, Kelli P. A.; Smyth, Mark J.; Degli-Esposti, Mariapia A.; Hill, Geoffrey R.
BLOOD - 1/02/2017
IL-17A-Producing gammadelta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver
Sheel, Meru; Beattie, L; Frame, Teija C. M.; Rivera, Fabian de Labastida; Faleiro, Rebecca; Bunn, Patrick T.; de Oca, Marcela Montes; Edwards, Chelsea L.; Ng, Susanna S.; Kumar, Rajiv; Amante, FH; Best, Shannon E.; McColl, Shaun R.; Varelias, Antiopi; Kuns, Rachel; MacDonald, Kelli P. A.; Smyth, Mark J.; Haque, Ashraful; Hill, Geoffrey R.; Engwerda, C
JOURNAL OF IMMUNOLOGY - 1/12/2015
Allergen-induced IL-6 trans-signaling activates gammadelta T cells to promote type 2 and type 17 airway inflammation
Ullah, Ashik; Revez, Joana A.; Loh, Zhixuan; Simpson, Jennifer; Zhang, Vivian; Bain, L.; Varelias, Antiopi; Rose-John, Stefan; Blumenthal, Antje; Smyth, M. J.; Hill, Geoffrey R.; Sukkar, Maria B.; Ferreira, Manuel A. R.; Phipps, Simon
The Journal of allergy and clinical immunology - 1/10/2015
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
Gartlan, Kate H.; Markey, Kate A.; Varelias, Antiopi; Bunting, Mark D.; Koyama, Motoko; Kuns, Rachel; Raffelt, Neil C.; Olver, Stuart; Lineburg, Katie E.; Cheong, Melody; Teal, Bianca E.; Lor, Mary; Comerford, Iain; Teng, Michele W. L.; Smyth, Mark J.; McCluskey, James; Rossjohn, Jamie; Stockinger, Brigitta; Boyle, GM; Lane, Steven W.; Clouston, AD; McColl, Shaun R.; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD - 1/09/2015
Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease
Koyama, Motoko; Cheong, Melody; Markey, Kate A.; Gartlan, Kate H.; Kuns, Rachel; Locke, Kelly R.; Lineburg, Katie E.; Teal, Bianca E.; Leveque-El Mouttie, Lucie; Bunting, Mark D.; Vuckovic, Slavica; Zhang, Ping; Teng, Michele W. L.; Varelias, Antiopi; Tey, Siok-Keen; Wockner, Leesa; Engwerda, C; Smyth, Mark J.; Belz, Gabrielle T.; McColl, Shaun R.; MacDonald, Kelli P. A.; Hill, Geoffrey R.
JOURNAL OF EXPERIMENTAL MEDICINE - 1/07/2015
Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial
Kennedy, G; Varelias, Antiopi; Vuckovic, Slavica; Le Texier, Laetitia; Gartlan, Kate H.; Zhang, Ping; Thomas, Gethin; Anderson, Lisa; Boyle, GM; Cloonan, Nicole; Leach, Justine; Sturgeon, Elise; Avery, Judy; Olver, Stuart; Lor, Mary; Misra, Ashish K.; Hutchins, Cheryl; Morton, A. James; Durrant, S; Subramoniapillai, Elango; Butler, Jason P.; Curley, Cameron I.; MacDonald, Kelli P. A.; Tey, Siok-Keen; Hill, Geoffrey R.
The Lancet. Oncology - 1/12/2014
Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial
Kennedy, G; Varelias, Antiopi; Vuckovic, Slavica; Le Texier, Laetitia; Gartlan, Kate H.; Zhang, Ping; Thomas, Gethin; Anderson, Lisa; Boyle, GM; Cloonan, Nicole; Leach, Justine; Sturgeon, Elise; Avery, Judy; Olver, Stuart; Lor, Mary; Misra, Ashish K.; Hutchins, Cheryl; Morton, A. James; Durrant, S; Subramoniapillai, Elango; Butler, Jason P.; Curley, Cameron I.; MacDonald, Kelli P. A.; Tey, Siok-Keen; Hill, Geoffrey R.
The Lancet. Oncology - 1/12/2014
CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease
Alexander, Kylie A.; Flynn, Ryan; Lineburg, Katie E.; Kuns, Rachel; Teal, Bianca E.; Olver, Stuart; Lor, Mary; Raffelt, Neil C.; Koyama, Motoko; Leveque, Lucie; Le Texier, Laetitia; Melino, Michelle; Markey, Kate A.; Varelias, Antiopi; Engwerda, CR; Serody, Jonathan S.; Janela, Baptiste; Ginhoux, Florent; Clouston, AD; Blazar, Bruce R.; Hill, Geoffrey R.; MacDonald, Kelli P. A.
THE JOURNAL OF CLINICAL INVESTIGATION - 1/10/2014
NHMRC - 496689
CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease
Alexander, Kylie A.; Flynn, Ryan; Lineburg, Katie E.; Kuns, Rachel; Teal, Bianca E.; Olver, Stuart; Lor, Mary; Raffelt, Neil C.; Koyama, Motoko; Leveque, Lucie; Le Texier, Laetitia; Melino, Michelle; Markey, Kate A.; Varelias, Antiopi; Engwerda, CR; Serody, Jonathan S.; Janela, Baptiste; Ginhoux, Florent; Clouston, AD; Blazar, Bruce R.; Hill, Geoffrey R.; MacDonald, Kelli P. A.
THE JOURNAL OF CLINICAL INVESTIGATION - 1/10/2014
NHMRC - 496689
Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity
Haque, Ashraful; Best, Shannon E.; de Oca, Marcela Montes; James, Kylie R.; Ammerdorffer, Anne; Edwards, Chelsea L.; Rivera, Fabian de Labastida; Amante, FH; Bunn, Patrick T.; Sheel, Meru; Sebina, Ismail; Koyama, Motoko; Varelias, Antiopi; Hertzog, Paul; Kalinke, Ulrich; Gun, Sin Yee; Renia, Laurent; Ruedl, Christiane; MacDonald, Kelli P. A.; Hill, Geoffrey R.; Engwerda, CR
THE JOURNAL OF CLINICAL INVESTIGATION - 1/06/2014
Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo
Zhang, Ping; Tey, Siok-Keen; Koyama, Motoko; Kuns, Rachel; Olver, Stuart; Lineburg, Katie E.; Lor, Mary; Teal, Bianca E.; Raffelt, Neil C.; Raju, Jyothy; Leveque, Lucie; Markey, Kate A.; Varelias, Antiopi; Clouston, AD; Lane, Steve W.; MacDonald, Kelli P. A.; Hill, Geoffrey R.
JOURNAL OF IMMUNOLOGY - 1/11/2013
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
Robb, Renee J.; Lineburg, Katie E.; Kuns, Rachel; Wilson, Yana A.; Raffelt, Neil C.; Olver, Stuart; Varelias, Antiopi; Alexander, Kylie A.; Teal, Bianca E.; Sparwasser, Tim; Hammerling, Gunter J.; Markey, Kate A.; Koyama, Motoko; Clouston, AD; Engwerda, CR; Hill, Geoffrey R.; MacDonald, Kelli P. A.
BLOOD - 1/07/2012
Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.
Markey, Kate A.; Koyama, Motoko; Kuns, Rachel; Lineburg, Katie E.; Wilson, Yana A.; Olver, Stuart; Raffelt, Neil C.; Don, A; Varelias, Antiopi; Robb, Renee J.; Cheong, Melody; Engwerda, CR; Steptoe, Raymond J.; Ramshaw, Hayley S.; Lopez, Angel F.; Vega-Ramos, Javier; Lew, AM; Villadangos, Jose A.; Hill, Geoffrey R.; MacDonald, Kelli P. A.
BLOOD - 1/07/2012
Type I-IFNs control GVHD and GVL responses after transplantation
Robb, Renee J.; Kreijveld, Ellen; Kuns, Rachel; Wilson, Yana A.; Olver, Stuart; Don, A; Raffelt, Neil C.; De Weerd, Nicole A.; Lineburg, Katie E.; Varelias, Antiopi; Markey, Kate A.; Koyama, Motoko; Clouston, AD; Hertzog, Paul; MacDonald, Kelli P. A.; Hill, Geoffrey R.
BLOOD - 22/09/2011
