QIMR Berghofer
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Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae
Kalimutho, Murugan; Bain, Amanda L.; Mukherjee, Bipasha; Nag, Purba; Nanayakkara, Devathri M.; Harten, Sarah K.; Harris, Janelle L.; Subramanian, Goutham N.; Sinha, Debottam; Shirasawa, Senji; Srihari, Sriganesh; Burma, Sandeep; Khanna, Kum Kum
MOLECULAR ONCOLOGY - 1/05/2017
Cancer Council Queensland (CCQ) Project Grant - 1087363
Identification of ATM-Interacting Proteins by Co-immunoprecipitation and Glutathione-S-Transferase (GST) Pull-Down Assays.
Bain, Amanda L; Harris, Janelle L; Khanna, Kum Kum
Methods in Molecular Biology - 1/05/2017
Whole-genome landscape of pancreatic neuroendocrine tumours
Scarpa, Aldo; Chang, David K.; Nones, Katia; Corbo, Vincenzo; Patch, Ann-Marie; Bailey, Peter; Lawlor, Rita T.; Johns, Amber L.; Miller, David K.; Mafficini, Andrea; Rusev, Borislav; Scardoni, Maria; Antonello, Davide; Barbi, Stefano; Sikora, Katarzyna O.; Cingarlini, Sara; Vicentini, Caterina; Mckay, Skye; Quinn, Michael C. J.; Bruxner, Timothy J. C.; Christ, Angelika N.; Harliwong, Ivon; Idrisoglu, Senel; McLean, Suzanne; Nourse, Craig; Nourbakhsh, Ehsan; Wilson, Peter J.; Anderson, Matthew J.; Fink, J. Lynn; Newell, Felicity; Waddell, Nick; Holmes, Oliver; Kazakoff, Stephen H.; Leonard, Conrad; Wood, Scott; Xu, Qinying; Nagaraj, Shivashankar Hiriyur; Amato, Eliana; Dalai, Irene; Bersanif, Samantha; Cataldo, Ivana; Tos, Angelo P. Dei; Capelli, Paola; Davi, Maria Vittoria; Landoni, Luca; Malpaga, Anna; Miotto, Marco; Whitehall, Vicki L. J.; Leggett, Barbara A.; Harris, Janelle L.; Harris, Jonathan; Jones, Marc D.; Humphris, Jeremy; Chantrill, Lorraine A.; Chin, Venessa; Nagrial, Adnan M.; Pajic, Marina; Scarlett, Christopher J.; Pinho, Andreia; Rooman, Ilse; Toon, Christopher; Wu, Jianmin; Pinese, Mark; Cowley, Mark; Barbour, Andrew; Mawson, Amanda; Humphrey, Emily S.; Colvin, Emily K.; Chou, Angela; Lovell, Jessica A.; Jamieson, Nigel B.; Duthie, Fraser; Gingras, Marie-Claude; Fisher, William E.; Dagg, Rebecca A.; Lau, Loretta M. S.; Lee, Michael; Pickett, Hilda A.; Reddel, Roger R.; Samra, Jaswinder S.; Kench, James G.; Merrett, Neil D.; Epari, Krishna; Nguyen, Nam Q.; Zeps, Nikolajs; Falconi, Massimo; Simbolo, Michele; Butturini, Giovanni; Van Buren, George, II; Partelli, Stefano; Fassan, Matteo; Khanna, Kum Kum; Gill, Anthony J.; Wheeler, David A.; Gibbs, Richard A.; Musgrove, Elizabeth A.; Bassi, Claudio; Tortora, Giampaolo; Pederzoli, Paolo; Pearson, John V.; Waddell, Nicola; Biankin, Andrew V.; Grimmond, Sean M.
NATURE - 1/03/2017
Italian Ministry of Research - FIRB RBAP10AHJB
The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells
Anderson, Alison M.; Kalimutho, Murugan; Harten, Sarah; Nanayakkara, Devathri M.; Khanna, Kum Kum; Ragan, Mark A.
SCIENTIFIC REPORTS - 1/01/2017
Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer
Liu, Chao; Rohart, Florian; Simpson, Peter T.; Khanna, Kum Kum; Ragan, Mark A.; Le Cao, Kim-Anh
SCIENTIFIC REPORTS - 1/09/2016
Australian National Health and Medical Research Council (NHMRC) - 1028742
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Lawrenson, Kate; Kar, Siddhartha; Mccue, Karen; Kuchenbaeker, Karoline; Michailidou, Kyriaki; Tyrer, Jonathan; Beesley, Jonathan; Ramus, Susan J.; Li, Qiyuan; Delgado, Melissa K.; Lee, Janet M.; Aittomaki, Kristiina; Andrulis, Irene L.; Anton-Culver, Hoda; Arndt, Volker; Arun, Banu K.; Arver, Brita; Bandera, Elisa V.; Barile, Monica; Barkardottir, Rosa B.; Barrowdale, Daniel; Beckmann, Matthias W.; Benitez, Javier; Berchuck, Andrew; Bisogna, Maria; Bjorge, Line; Blomqvist, Carl; Blot, William; Bogdanova, Natalia; Bojesen, Anders; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Bruinsma, Fiona; Brunet, Joan; Buhari, Shaik Ahmad; Burwinkel, Barbara; Butzow, Ralf; Buys, Saundra S.; Cai, Qiuyin; Caldes, Trinidad; Campbell, Ian; Canniotto, Rikki; Chang-Claude, Jenny; Chiquette, Jocelyne; Choi, Ji-Yeob; Claes, Kathleen B. M.; Cook, Linda S.; Cox, Angela; Cramer, Daniel W.; Cross, Simon S.; Cybulski, Cezary; Czene, Kamila; Daly, Mary B.; Damiola, Francesca; Dansonka-Mieszkowska, Agnieszka; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Diez, Orland; Doherty, Jennifer A.; Domchek, Susan M.; Dorfling, Cecilia M.; Doerk, Thilo; Dumont, Martine; Ehrencrona, Hans; Ejlertsen, Bent; Ellis, Steve; Engel, Christoph; Lee, Eunjung; Evans, D. Gareth; Fasching, Peter A.; Feliubadalo, Lidia; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Flyger, Henrik; Foretova, Lenka; Fostira, Florentia; Foulkes, William D.; Fridley, Brooke L.; Friedman, Eitan; Frost, Debra; Gambino, Gaetana; Ganz, Patricia A.; Garber, Judy; Garcia-Closas, Montserrat; Gentry-Maharaj, Aleksandra; Ghoussaini, Maya; Giles, Graham G.; Glasspool, Rosalind; Godwin, Andrew K.; Goldberg, Mark S.; Goldgar, David E.; Gonzalez-Neira, Anna; Goode, Ellen L.; Goodman, Marc T.; Greene, Mark H.; Gronwald, Jacek; Guenel, Pascal; Haiman, Christopher A.; Hall, Per; Hallberg, Emily; Hamann, Ute; Hansen, Thomas V. O.; Harrington, Patricia A.; Hartman, Mikael; Hassan, Norhashimah; Healey, Sue; Heitz, Florian; Herzog, Josef; Hogdall, Estrid; Hogdall, Claus K.; Hogervorst, Frans B. L.; Hollestelle, Antoinette; Hopper, John L.; Hulick, Peter J.; Huzarski, Tomasz; Imyanitov, Evgeny N.; Isaacs, Claudine; Ito, Hidemi; Jakubowska, Anna; Janavicius, Ramunas; Jensen, Allan; John, Esther M.; Johnson, Nichola; Kabisch, Maria; Kang, Daehee; Kapuscinski, Miroslav; Karlan, Beth Y.; Khan, Sofia; Kiemeney, Lambertus A.; Kjaer, Susanne Kruger; Knight, Julia A.; Konstantopoulou, Irene; Kosma, Veli-Matti; Kristensen, Vessela; Kupryjanczyk, Jolanta; Kwong, Ava; de la Hoya, Miguel; Laitman, Yael; Lambrechts, Diether; Le, Nhu; De Leeneer, Kim; Lester, Jenny; Levine, Douglas A.; Li, Jingmei; Lindblom, Annika; Long, Jirong; Lophatananon, Artitaya; Loud, Jennifer T.; Lu, Karen; Lubinski, Jan; Mannermaa, Arto; Manoukian, Siranoush; Le Marchand, Loic; Margolin, Sara; Marme, Frederik; Massuger, Leon F. A. G.; Matsuo, Keitaro; Mazoyer, Sylvie; McGuffog, Lesley; McLean, Catriona; McNeish, Iain; Meindl, Alfons; Menon, Usha; Mensenkamp, Arjen R.; Milne, Roger L.; Montagna, Marco; Moysich, Kirsten B.; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L.; Ness, Roberta B.; Neuhausen, Susan L.; Nevanlinna, Heli; Nord, Silje; Nussbaum, Robert L.; Odunsi, Kunle; Offit, Kenneth; Olah, Edith; Olopade, Olufunmilayo I.; Olson, Janet E.; Olswold, Curtis; O'Malley, David; Orlow, Irene; Orr, Nick; Osorio, Ana; Park, Sue Kyung; Pearce, Celeste L.; Pejovic, Tanja; Peterlongo, Paolo; Pfeiler, Georg; Phelan, Catherine M.; Poole, Elizabeth M.; Pylkas, Katri; Radice, Paolo; Rantala, Johanna; Rashid, Muhammad Usman; Rennert, Gad; Rhenius, Valerie; Rhiem, Kerstin; Risch, Harvey A.; Rodriguez, Gus; Rossing, Mary Anne; Rudolph, Anja; Salvesen, Helga B.; Sangrajrang, Suleeporn; Sawyer, Elinor J.; Schildkraut, Joellen M.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Sellers, Thomas A.; Seynaeve, Caroline; Shah, Mitul; Shen, Chen-Yang; Shu, Xiao-Ou; Sieh, Weiva; Singer, Christian F.; Sinilnikova, Olga M.; Slager, Susan; Song, Honglin; Soucy, Penny; Southey, Melissa C.; Stenmark-Askmalm, Marie; Stoppa-Lyonnet, Dominique; Sutter, Christian; Swerdlow, Anthony; Tchatchou, Sandrine; Teixeira, Manuel R.; Teo, Soo H.; Terry, Kathryn L.; Terry, Mary Beth; Thomassen, Mads; Tibiletti, Maria Grazia; Tihomirova, Laima; Tognazzo, Silvia; Toland, Amanda Ewart; Tomlinson, Ian; Torres, Diana; Truong, Therese; Tseng, Chiu-Chen; Tung, Nadine; Tworoger, Shelley S.; Vachon, Celine; van den Ouweland, Ans M. W.; van Doorn, Helena C.; van Rensburg, Elizabeth J.; Van't Veer, Laura J.; Vanderstichele, Adriaan; Vergote, Ignace; Vijai, Joseph; Wang, Qin; Wang-Gohrke, Shan; Weitzel, Jeffrey N.; Wentzensen, Nicolas; Whittemore, Alice S.; Wildiers, Hans; Winqvist, Robert; Wu, Anna H.; Yannoukakos, Drakoulis; Yoon, Sook-Yee; Yu, Jyh-Cherng; Zheng, Wei; Zheng, Ying; Khanna, Kum Kum; Simard, Jacques; Monteiro, Alvaro N.; French, Juliet D.; Couch, Fergus J.; Freedman, Matthew L.; Easton, Douglas F.; Dunning, Alison M.; Pharoah, Paul D.; Edwards, Stacey L.; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Gayther, Simon A.
Nature Communications - 1/09/2016
National Cancer Institute (USA) - UM1 CA164920
Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis
Mittal, Deepak; Sinha, Debottam; Barkauskas, Deborah; Young, Arabella; Kalimutho, Murugan; Stannard, Kimberley; Caramia, Franco; Haibe-Kains, Benjamin; Stagg, John; Khanna, Kum Kum; Loi, Sherene; Smyth, Mark J.
CANCER RESEARCH - 1/08/2016
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
Quin, Jaclyn; Chan, Keefe T.; Devlin, Jennifer R.; Cameron, Donald P.; Diesch, Jeannine; Cullinane, Carleen; Ahern, Jessica; Khot, Amit; Hein, Nadine; George, Amee J.; Hannan, Katherine M.; Poortinga, Gretchen; Sheppard, Karen E.; Khanna, Kum Kum; Johnstone, Ricky W.; Drygin, Denis; McArthur, Grant A.; Pearson, Richard B.; Sanij, Elaine; Hannan, Ross D.
ONCOTARGET - 1/08/2016
National Health and Medical Research Council (NHMRC) of Australia - 1043884
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer
French, Juliet D.; Johnatty, Sharon E.; Lu, Yi; Beesley, Jonathan; Gao, Bo; Kalimutho, Murugan; Henderson, Michelle J.; Russell, Amanda J.; Kar, Siddhartha; Chen, Xiaoqing; Hillman, Kristine M.; Kaufmann, Susanne; Sivakumaran, Haran; O'Reilly, Martin; Wang, Chen; Korbie, Darren J.; Lambrechts, Diether; Despierre, Evelyn; Van Nieuwenhuysen, Els; Lambrechts, Sandrina; Vergote, Ignace; Karlan, Beth; Lester, Jenny; Orsulic, Sandra; Walsh, Christine; Fasching, Peter A.; Beckmann, Matthias W.; Ekici, Arif B.; Hein, Alexander; Matsuo, Keitaro; Hosono, Satoyo; Pisterer, Jacobus; Hillemanns, Peter; Nakanishi, Toru; Yatabe, Yasushi; Goodman, Marc T.; Lurie, Galina; Matsuno, Rayna K.; Thompson, Pamela J.; Pejovic, Tanja; Bean, Yukie; Heitz, Florian; Harter, Philipp; du Bois, Andreas; Schwaab, Ira; Hogdall, Estrid; Kjaer, Susanne K.; Jensen, Allan; Hogdall, Claus; Lundvall, Lene; Engelholm, Svend Aage; Brown, Bob; Flanagan, James M.; Metcalf, Michelle D.; Siddiqui, Nadeem; Sellers, Thomas; Fridley, Brooke; Cunningham, Julie; Schildkraut, Joellen M.; Iversen, Ed; Weber, Rachel Palmieri; Brennan, Donal; Berchuck, Andrew; Pharoah, Paul; Harnett, Paul; Norris, Murray D.; Haber, Michelle; Goode, Ellen L.; Lee, Jason S.; Khanna, Kum Kum; Meyer, Kerstin B.; Chenevix-Trench, Georgia; deFazio, Anna; Edwards, Stacey L.; Macgregor, Stuart
ONCOTARGET - 1/02/2016
High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations
Johnston, Rebecca L.; Wockner, Leesa; Reed, Amy E. McCart; Wiegmans, Adrian; Chenevix-Trench, Georgia; Khanna, Kum Kum; Lakhani, Sunil R.; Smart, Chanel E.
BREAST CANCER RESEARCH - 1/02/2016
Understanding the functional impact of copy number alterations in breast cancer using a network modeling approach
Srihari, Sriganesh; Kalimutho, Murugan; Lal, Samir; Singla, Jitin; Patel, Dhaval; Simpson, Peter T.; Khanna, Kum Kum; Ragan, Mark A.
MOLECULAR BIOSYSTEMS - 1/01/2016
Australian National Health & Medical Research Council (NHMRC) grant - 1028742
Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease
Kalimutho, Murugan; Parsons, Kate; Mittal, Deepak; Lopez, JA; Srihari, Sriganesh; Khanna, Kum Kum
TRENDS IN PHARMACOLOGICAL SCIENCES - 1/12/2015
Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance
Saunus, Jodi M.; Quinn, Michael C. J.; Patch, Ann-Marie; Pearson, John V.; Bailey, Peter J.; Nones, Katia; Reed, Amy E. McCart; Miller, David; Wilson, P; Al-Ejeh, Fares; Mariasegaram, Mythily; Lau, Queenie; Withers, Teresa; Jeffree, Rosalind L.; Reid, L.; Da Silva, Leonard; Matsika, Admire; Niland, Colleen M.; Cummings, M; Bruxner, Timothy J. C.; Christ, Angelika N.; Harliwong, Ivon; Idrisoglu, Senel; Manning, Suzanne; Nourse, Craig; Nourbakhsh, Ehsan; Wani, Shivangi; Anderson, Matthew J.; Fink, J. Lynn; Holmes, Oliver; Kazakoff, Stephen; Leonard, Conrad; Newell, Felicity; Taylor, DF; Waddell, Nic; Wood, Scott; Xu, Qinying; Kassahn, Karin S.; Narayanan, Vairavan; Taib, Nur Aishah Mohd; Teo, Soo Hwang; Chow, Yock Ping; Jat, Parmjit S.; Brandner, Sebastian; Flanagan, Adrienne M.; Khanna, Kum Kum; Chenevix-Trench, G; Grimmond, Sean; Simpson, PT; Lakhani, S. R.
JOURNAL OF PATHOLOGY - 1/11/2015
NHMRC - APP1030751
Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition
Wiegmans, A.; Yap, Pei-Yi; Ward, Ambber; Lim, Yi Chieh; Khanna, Kum Kum
MOLECULAR CANCER THERAPEUTICS - 1/10/2015
Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer
Liu, Chao; Srihari, Sriganesh; Lal, Samir; Gautier, Benoit; Simpson, PT; Khanna, Kum Kum; Ragan, Mark A.; Le Cao, Kim-Anh
MOLECULAR ONCOLOGY - 26/09/2015
Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish
Jeffery, Jessie; Neyt, Christine; Moore, Wade; Paterson, Scott; Bower, Neil I.; Chenevix-Trench, Georgia; Verkade, Heather; Hogan, Benjamin M.; Khanna, Kum Kum
FASEB JOURNAL - 1/05/2015
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib
Bessette, Darrell C.; Tilch, E.; Seidens, T.; Quinn, Michael C. J.; Wiegmans, A.; Shi, Wei; Cocciardi, Sibylle; McCart-Reed, Amy; Saunus, Jodi M.; Simpson, PT; Grimmond, Sean; Lakhani, S. R.; Khanna, Kum Kum; Waddell, Nic; Al-Ejeh, Fares; Chenevix-Trench, Georgia
PLOS ONE - 1/05/2015
The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin
Kalousi, Alkmini; Hoffbeck, Anne-Sophie; Selemenakis, Platonas N.; Pinder, Jordan; Savage, Kienan I.; Khanna, Kum Kum; Brino, Laurent; Dellaire, Graham; Gorgoulis, Vassilis G.; Soutoglou, Evi
Cell Reports - 7/04/2015
The Integrator complex controls the termination of transcription at diverse classes of gene targets
Skaar, Jeffrey R.; Ferris, Andrea L.; Wu, Xiaolin; Saraf, Anita; Khanna, Kum Kum; Florens, Laurence; Washburn, Michael P.; Hughes, Stephen H.; Pagano, Michele
CELL RESEARCH - 1/03/2015
Genomic and transcriptomic landscapes of human brain metastases
Saunus, Jodi M.; Quinn, M. C. J.; Patch, A. M.; Pearson, J. V.; Bailey, P. J.; Cloonan, N.; Nones, K.; Miller, D.; Mariasegaram, M.; Lau, Q.; Jeffree, L.; Khanna, Kum Kum; Chenevix-Trench, G.; Grimmond, S. M.; Simpson, P.; Waddell, Nic; Lakhani, S. R.
Clinical and Experimental Metastasis - 1/03/2015