Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
Rashidieh, Behnam; Shohayeb, Belal; Bain, Amanda Louise; Fortuna, Patrick R J; Sinha, Debottam; Burgess, Andrew; Mills, Richard; Adams, Rachael C; Lopez, J Alejandro; Blumbergs, Peter; Finnie, John; Kalimutho, Murugan; Piper, Michael; Hudson, James Edward; Ng, Dominic C H; Khanna, Kum Kum
PLOS GENETICS - 1/01/2021
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
McMahon, Kerrie-Ann; Stroud, David A; Gambin, Yann; Tillu, Vikas; Bastiani, Michele; Sierecki, Emma; Polinkovsky, Mark E; Hall, Thomas E; Gomez, Guillermo A; Wu, Yeping; Parat, Marie-Odile; Martel, Nick; Lo, Harriet P; Khanna, Kum Kum; Alexandrov, Kirill; Daly, Roger; Yap, Alpha; Ryan, Michael T; Parton, Robert G
Elife - 1/01/2021
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Sinha, Debottam; Nag, Purba; Nanayakkara, Devathri; Duijf, Pascal H G; Burgess, Andrew; Raninga, Prahlad; Smits, Veronique A J; Bain, Amanda L; Subramanian, Goutham; Wall, Meaghan; Finnie, John W; Kalimutho, Murugan; Khanna, Kum Kum
Communications Biology - 1/10/2020
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.
Sanij, Elaine; Hannan, Katherine; Xuan, Jiachen; Yan, Shunfei; Ahern, Jessica A.; Trigos, Anna S.; Brajanovski, Natalie; Son, Jinbae; Chan, Keefe T.; Kondrashova, Olga; Lieschke, Elizabeth; Wakefield, Matthew J.; Ellis, Sarah; Cullinane, Carleen; Poortinga, Gretchen; Khanna, Kum Kum; Mileshkin, Linda; McArthur, Grant A.; Soong, John; Berns, Els M.; Hannan, Ross D.; Scott, Clare L.; Sheppard, Karen E.; Pearson, Richard B.
CLINICAL CANCER RESEARCH - 1/07/2020