Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.
Li, Xian-Yang; Moesta, Achim K; Xiao, Christos; Nakamura, Kyohei; Casey, Mika; Zhang, Haiyan; Madore, Jason; Lepletier, Ailin; Aguilera, Amelia Roman; Sundarrajan, Ashmitha; Jacoberger-Foissac, Celia; Wong, Clifford; Dela Cruz, Tracy; Welch, Megan; Lerner, Alana G; Spatola, Bradley N; Soros, Vanessa B; Corbin, John; Anderson, Ana C; Effern, Maike; Hölzel, Michael; Robson, Simon C; Johnston, Rebecca L; Waddell, Nicola; Smith, Corey; Bald, Tobias; Geetha, Nishamol; Beers, Courtney; Teng, Michele W L; Smyth, Mark J
CANCER DISCOVERY - 1/11/2019
NCI NIH HHS - R21 CA221702
MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.
Koyama, Motoko; Mukhopadhyay, Pamela; Schuster, Iona S; Henden, Andrea S; Hülsdünker, Jan; Varelias, Antiopi; Vetizou, Marie; Kuns, Rachel D; Robb, Renee J; Zhang, Ping; Blazar, Bruce B; Thomas, Ranjeny; Begun, Jakob; Waddell, Nicola; Trinchieri, Giorgio; Zeiser, Robert; Clouston, Andrew D; Degli-Esposti, Mariapia A; Hill, Geoffrey R
IMMUNITY - 1/09/2019
NHLBI NIH HHS - R01 HL148164
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
Vennin, Claire; Melenec, Pauline; Rouet, Romain; Nobis, Max; Cazet, Aurelie S.; Murphy, Kendelle J.; Herrmann, David; Reed, Daniel A.; Lucas, Morghan C.; Warren, Sean C.; Elgundi, Zehra; Pinese, Mark; Kalna, Gabriella; Roden, Daniel; Samuel, Monisha; Zaratzian, Anaiis; Grey, Shane T.; Da Silva, Andrew; Leung, Wilfred; Mathivanan, Suresh; Wang, Yingxiao; Braithwaite, Anthony W.; Christ, Daniel; Benda, Ales; Parkin, Ashleigh; Phillips, Phoebe A.; Whitelock, John M.; Gill, Anthony J.; Sansom, Owen J.; Croucher, David R.; Parker, Benjamin L.; Pajic, Marina; Morton, Jennifer P.; Cox, Thomas R.; Timpson, Paul; Johns, Amber L.; Chantrill, Lorraine A.; Chou, Angela; Steinmann, Angela; Arshi, Mehreen; Dwarte, Tanya; Froio, Danielle; Pereira, Brooke; Ritchie, Shona; Chambers, Cecilia R.; Metcalf, Xanthe; Waddell, Nicola; Pearson, John, V; Patch, Ann-Marie; Nones, Katia; Newell, Felicity; Mukhopadhyay, Pamela; Addala, Venkateswar; Kazakoff, Stephen; Holmes, Oliver; Leonard, Conrad; Wood, Scott; Grimmond, Sean M.; Hofmann, Oliver; Christ, Angelika; Bruxner, Tim; Samra, Jaswinder S.; Pavlakis, Nick; High, Hilda A.; Asghari, Ray; Merrett, Neil D.; Pavey, Darren; Das, Amitabha; Cosman, Peter H.; Ismail, Kasim; O'Connnor, Chelsie; Stoita, Alina; Williams, David; Spigellman, Allan; Lam, Vincent W.; McLeod, Duncan; Kirk, Judy; Kench, James G.; Grimison, Peter; Cooper, Caroline L.; Sandroussi, Charbel; Goodwin, Annabel; Mead, R. Scott; Tucker, Katherine; Andrews, Lesley; Texler, Michael; Forest, Cindy; Epari, Krishna P.; Ballal, Mo; Fletcher, David R.; Mukhedkar, Sanjay; Zeps, Nikolajs; Beilin, Maria; Feeney, Kynan; Nguyen, Nan Q.; Ruszkiewicz, Andrew R.; Worthley, Chris; Chen, John; Brooke-Smith, Mark E.; Papangelis, Virginia; Clouston, Andrew D.; Barbour, Andrew P.; O'Rourke, Thomas J.; Fawcett, Jonathan W.; Slater, Kellee; Hatzifotis, Michael; Hodgkinson, Peter; Nikfarjam, Mehrdad; Eshleman, James R.; Hruban, Ralph H.; Wolfgang, Christopher L.; Lawlor, Rita T.; Beghelli, Stefania; Corbo, Vincenzo; Scardoni, Maria; Bassi, Claudio; Biankin, Andrew, V; Dixon, Judith; Jamieson, Nigel B.; Chang, David K.
Nature Communications - 1/08/2019
Running Genomic Analyses in the Cloud.
Leonard, Conrad; Wood, Scott; Holmes, Oliver; Waddell, Nic; Gorse, Dominique; Hansen, David P; Pearson, John V
Studies in Health Technology and Informatics - 1/08/2019
Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.
Newell, Felicity; Kong, Yan; Wilmott, James S; Johansson, Peter A; Ferguson, Peter M; Cui, Chuanliang; Li, Zhongwu; Kazakoff, Stephen H; Burke, Hazel; Dodds, Tristan J; Patch, Ann-Marie; Nones, Katia; Tembe, Varsha; Shang, Ping; van der Weyden, Louise; Wong, Kim; Holmes, Oliver; Lo, Serigne; Leonard, Conrad; Wood, Scott; Xu, Qinying; Rawson, Robert V; Mukhopadhyay, Pamela; Dummer, Reinhard; Levesque, Mitchell P; Jönsson, Göran; Wang, Xuan; Yeh, Iwei; Wu, Hong; Joseph, Nancy; Bastian, Boris C; Long, Georgina V; Spillane, Andrew J; Shannon, Kerwin F; Thompson, John F; Saw, Robyn P M; Adams, David J; Si, Lu; Pearson, John V; Hayward, Nicholas K; Waddell, Nicola; Mann, Graham J; Guo, Jun; Scolyer, Richard A
Nature Communications - 1/07/2019
Programmed death-1 ligand 2 (PD-L2) on dendritic cells protects T cells from cellular exhaustion during melanoma
Faleiro, Rebecca J.; Karunarathne, Deshapriya S.; Liu, Ji; Boyle, Glen; Hartel, Gunter; Hayward, Nick; Schaider, Helmut; Waddell, Nic; Schmidt, Chris; Wykes, Michelle
CANCER RESEARCH - 1/07/2019
BRAF and KRAS mutation define distinct subtypes of the CpG island methylator phenotype in colorectal cancers
Whitehall, Vicki L.; Fennell, Lochlan; Dumenil, Troy; Hertel, Gunter; Nones, Katia; Bond, Catherine; McKeone, Diane; Patch, Ann-Marie; Kazakoff, Stephen; Pearson, John; Waddell, Nicola; Wirapati, Pratyaksha; Lochead, Paul; Ogino, Shuji; Tejpar, Sabine; Leggett, Barbara
CANCER RESEARCH - 1/07/2019
Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology
Koyama, Motoko; Mukhopadhyay, Pamela; Schuster, Iona S.; Henden, Andrea S.; Hulsdunker, Jan; Varelias, Antiopi; Vetizou, Marie; Kuns, Rachel D.; Robb, Renee J.; Zhang, Ping; Blazar, Bruce R.; Thomas, Ranjeny; Begun, Jakob; Waddell, Nicola; Trinchieri, Giorgio; Zeiser, Robert; Clouston, Andrew D.; Degli-Esposti, Mariapia A.; Hill, Geoffrey R.
JOURNAL OF IMMUNOLOGY - 1/05/2019
Comprehensive molecular profiling of metastatic melanoma to predict response to monotherapy and combination immunotherapy.
Da Silva, Ines Esteves Domingues Pires; Menzies, Alexander M.; Newell, Felicity; Wilmott, James S.; Carlino, Matteo S.; Ferguson, Peter M.; Edwards, Jarem; Spillane, Andrew; Shannon, Kerwin; Saw, Robyn; Thompson, John F.; Rizos, Helen; Mann, Graham J.; Johansson, Peter; Hayward, Nicholas; Scolyer, Richard A.; Waddell, Nic; Long, Georgina V.
JOURNAL OF CLINICAL ONCOLOGY - 1/05/2019
Integrative genome-scale DNA Methylation analysis of a large and unselected cohort reveals five distinct subtypes of Colorectal Adenocarcinomas.
Fennell, Lochlan; Dumenil, Troy; Wockner, Leesa; Hartel, Gunter; Nones, Katia; Bond, Catherine; Borowsky, Jennifer; Liu, Cheng; McKeone, Diane; Bowdler, Lisa; Montgomery, Grant; Klein, Kerenaftali; Hoffmann, Isabell; Patch, Ann-Marie; Kazakoff, Stephen; Pearson, John; Waddell, Nicola; Wirapati, Pratyaksha; Lochhead, Paul; Imamura, Yu; Ogino, Shuji; Shao, Renfu; Tejpar, Sabine; Leggett, Barbara; Whitehall, Vicki
Cellular and molecular gastroenterology and hepatology - 1/04/2019
NCI NIH HHS - R35 CA197735
Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples.
Newell, Felicity; Patel, Kalpana; Gartside, Michael; Krause, Lutz; Brosda, Sandra; Aoude, Lauren G; Loffler, Kelly A; Bonazzi, Vanessa F; Patch, Ann-Marie; Kazakoff, Stephen H; Holmes, Oliver; Xu, Qinying; Wood, Scott; Leonard, Conrad; Lampe, Guy; Lord, Reginald V; Whiteman, David C; Pearson, John V; Nones, Katia; Waddell, Nicola; Barbour, Andrew P
BMC Medical Genomics - 1/02/2019
National Health and Medical Research Council - APP1021403
Diff-Quik Cytology Smears from Endobronchial Ultrasound Transbronchial Needle Aspiration Lymph Node Specimens as a Source of DNA for Next-Generation Sequencing Instead of Cell Blocks.
Fielding, David; Dalley, Andrew J; Bashirzadeh, Farzad; Singh, Mahendra; Nandakumar, Lakshmy; McCart Reed, Amy E; Black, Debra; Kazakoff, Stephen; Pearson, John V; Nones, Katia; Waddell, Nicola; Lakhani, Sunil R; Simpson, Peter T
Respiration: International Review of Thoracic Diseases - 1/02/2019
Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma.
Akgül, Seçkin; Patch, Ann-Marie; D'Souza, Rochelle C J; Mukhopadhyay, Pamela; Nones, Katia; Kempe, Sarah; Kazakoff, Stephen H; Jeffree, Rosalind L; Stringer, Brett W; Pearson, John V; Waddell, Nicola; Day, Bryan W
Cancers - 1/02/2019
National Health and Medical Research Council - 1139071
Molecular genomic profiling of melanocytic nevi.
Colebatch, Andrew J; Ferguson, Peter; Newell, Felicity; Kazakoff, Stephen H; Witkowski, Tom; Dobrovic, Alexander; Johansson, Peter A; Saw, Robyn Pm; Stretch, Jonathan R; McArthur, Grant A; Long, Georgina V; Thompson, John F; Pearson, John V; Mann, Graham J; Hayward, Nicholas K; Waddell, Nicola; Scolyer, Richard A; Wilmott, James S
JOURNAL OF INVESTIGATIVE DERMATOLOGY - 1/02/2019
The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.
Zhao, Xiaobei; Little, Paul; Hoyle, Alan P; Pegna, Guillaume J; Hayward, Michele C; Ivanova, Anastasia; Parker, Joel S; Marron, David L; Soloway, Matthew G; Jo, Heejoon; Salazar, Ashley H; Papakonstantinou, Michael P; Bouchard, Deeanna M; Jefferys, Stuart R; Hoadley, Katherine A; Ollila, David W; Frank, Jill S; Thomas, Nancy E; Googe, Paul B; Ezzell, Ashley J; Collichio, Frances A; Lee, Carrie B; Earp, H Shelton; Sharpless, Norman E; Hugo, Willy; Wilmott, James S; Quek, Camelia; Waddell, Nicola; Johansson, Peter A; Thompson, John F; Hayward, Nicholas K; Mann, Graham J; Lo, Roger S; Johnson, Douglas B; Scolyer, Richard A; Hayes, D Neil; Moschos, Stergios J
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES - 1/01/2019
NCI NIH HHS - P30 CA016086
A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment.
Young, Arabella; Ngiow, Shin Foong; Gao, Yulong; Patch, Ann-Marie; Barkauskas, Deborah S; Messaoudene, Meriem; Lin, Gene; Coudert, Jerome David; Stannard, Kimberley A; Zitvogel, Laurence; Degli-Esposti, Mariapia A; Vivier, Eric; Waddell, Nicola; Linden, Joel; Huntington, Nicholas D; Souza-Fonseca Guimaraes, Fernando; Smyth, Mark J
CANCER RESEARCH - 1/12/2017
Interleukin-12 from CD103(+) Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis
Mittal, Deepak; Vijayan, Dipti; Putz, Eva M.; Aguilera, Amelia R.; Markey, Kate A.; Straube, Jasmin; Kazakoff, Stephen; Nutt, Stephen L.; Takeda, Kazuyoshi; Hill, Geoffrey R.; Waddell, Nicola; Smyth, Mark J.
Cancer Immunology Research - 1/12/2017
National Health and Medical Research Council of Australia (NHMRC) - 1078671
Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.
Chou, Angela; Froio, Danielle; Nagrial, Adnan M; Parkin, Ashleigh; Murphy, Kendelle J; Chin, Venessa T; Wohl, Dalia; Steinmann, Angela; Stark, Rhys; Drury, Alison; Walters, Stacey N; Vennin, Claire; Burgess, Andrew; Pinese, Mark; Chantrill, Lorraine A; Cowley, Mark J; Molloy, Timothy J; , ; Waddell, Nicola; Johns, Amber; Grimmond, Sean M; Chang, David K; Biankin, Andrew V; Sansom, Owen J; Morton, Jennifer P; Grey, Shane T; Cox, Thomas R; Turchini, John; Samra, Jaswinder; Clarke, Stephen J; Timpson, Paul; Gill, Anthony J; Pajic, Marina
GUT - 1/10/2017
Medical Research Council - MR/N005813/1
