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Addition of interleukin-2 overcomes resistance to neoadjuvant CTLA4 and PD1 blockade in ex vivo patient tumors.
Kaptein, Paulien; Jacoberger-Foissac, Celia; Dimitriadis, Petros; Voabil, Paula; de Bruijn, Marjolein; Brokamp, Simone; Reijers, Irene; Versluis, Judith; Nallan, Gahyathiri; Triscott, Hannah; McDonald, Elizabeth; Tay, Joshua; Long, Georgina V; Blank, Christian U; Thommen, Daniela S; Teng, Michele W L
Science Translational Medicine - 1/01/2022
ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis.
Nalkurthi, Christina; Schroder, Wayne A; Melino, Michelle; Irvine, Katharine M; Nyuydzefe, Melanie; Chen, Wei; Liu, Jing; Teng, Michele W L; Hill, Geoffrey R; Bertolino, Patrick; Blazar, Bruce R; Miller, Gregory C; Clouston, Andrew D; Zanin-Zhorov, Alexandra; MacDonald, Kelli P A
JHEP reports : innovation in hepatology - 1/01/2021
A prospective study investigating the efficacy and toxicity of definitive ChemoRadiation and ImmunOtherapy (CRIO) in locally and/or regionally advanced unresectable cutaneous squamous cell carcinoma
Lin, Charles; Ballah, Trishna; Nottage, Michelle; Hay, Karen; Chua, Benjamin; Kenny, Lizbeth; Thomas, Paul; Teng, Michele; Keller, Jacqui; Le, Trang; Edmunds, Jennifer; Hughes, Brett
RADIATION ONCOLOGY - 1/01/2021
Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 3rd-5th, 2020, Italy).
Ascierto, Paolo A; Blank, Christian; Dummer, Reinhard; Ernstoff, Marc S; Ferrone, Soldano; Fox, Bernard A; Gajewski, Thomas F; Garbe, Claus; Hwu, Patrick; Kalinski, Pawel; Krogsgaard, Michelle; Lo, Roger S; Luke, Jason J; Neyns, Bart; Postow, Michael A; Quezada, Sergio A; Teng, Michele W L; Trinchieri, Giorgio; Testori, Alessandro; Caracò, Corrado; Osman, Iman; Puzanov, Igor; Thurin, Magdalena
Journal Of Translational Medicine - 1/01/2021
Concomitant or delayed anti-TNF differentially impact on immune-related adverse events and antitumor efficacy after anti-CD40 therapy.
Jacoberger-Foissac, Celia; Blake, Stephen J; Liu, Jing; McDonald, Elizabeth; Triscott, Hannah; Nakamura, Kyohei; Smyth, Mark J; Teng, Michele Wl
Journal for immunotherapy of cancer - 1/11/2020
NH&MRC Career Development Fellowship - 1159655
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R
NATURE IMMUNOLOGY - 1/08/2020
Department of Health | National Health and Medical Research Council (NHMRC) - 1037304
Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma.
Guillerey, Camille; Stannard, Kimberley; Chen, Jason; Krumeich, Sophie; Miles, Kim; Nakamura, Kyohei; Smith, Jessica; Yu, Yuan; Ng, Susanna; Harjunpää, Heidi; Teng, Michele W L; Engwerda, Christian; Belz, Gabrielle T; Smyth, Mark J
IMMUNOLOGY AND CELL BIOLOGY - 1/08/2020
Cancer Australia - 1122183
Models for Immuno-oncology Research
Kuo, Calvin J.; Voest, Emile; Parrini, Maria Carla; Zou, Weiping; Teng, Michele W. L.; Greten, Tim F.; Palucka, Karolina; Gill, Saar; Joshi, Nikhil S.
CANCER CELL - 1/08/2020
Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma.
Lepletier, Ailin; Madore, Jason; O'Donnell, Jake S; Johnston, Rebecca L; Li, Xian-Yang; McDonald, Elizabeth; Ahern, Elizabeth; Kuchel, Anna; Eastgate, Melissa; Pearson, Sally-Ann; Mallardo, Domenico; Ascierto, Paolo A; Massi, Daniela; Merelli, Barbara; Mandala, Mario; Wilmott, James S; Menzies, Alexander M; Leduc, Charles; Stagg, John; Routy, Bertrand; Long, Georgina V; Scolyer, Richard A; Bald, Tobias; Waddell, Nicola; Dougall, William C; Teng, Michele W L; Smyth, Mark J
CLINICAL CANCER RESEARCH - 1/04/2020
Control of metastases via myeloid CD39 and NK cell effector function.
Yan, Juming; Li, Xian-Yang; Roman Aguilera, Amelia; Xiao, Christos; Jacoberger-Foisac, Celia; Nowlan, Bianca; Robson, Simon C; Beers, Courtney; Moesta, Achim K; Geetha, Nishamol; Teng, Michele W L; Smyth, Mark J
Cancer Immunology Research - 1/01/2020
NIAID NIH HHS - R01 AI132389
Pharmacodynamics of Pre-Operative PD1 checkpoint blockade and receptor activator of NFkB ligand (RANKL) inhibition in non-small cell lung cancer (NSCLC): study protocol for a multicentre, open-label, phase 1B/2, translational trial (POPCORN).
Ahern, Elizabeth; Cubitt, Annette; Ballard, Emma; Teng, Michele W L; Dougall, William C; Smyth, Mark J; Godbolt, David; Naidoo, Rishendran; Goldrick, Amanda; Hughes, Brett G M
Trials - 1/12/2019
MAIT cells promote tumor initiation, growth and metastases via tumor MR1.
Yan, Juming; Allen, Stacey; McDonald, Elizabeth; Das, Indrajit; Mak, Jeffrey Y W; Liu, Ligong; Fairlie, David P; Meehan, Bronwyn S; Chen, Zhenjun; Corbett, Alexandra J; Varelias, Antiopi; Smyth, Mark J; Teng, Michele W L
CANCER DISCOVERY - 1/12/2019
NH&MRC Research Fellowship - 1078671
IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.
Wang, Huimeng; Kjer-Nielsen, Lars; Shi, Mai; D'Souza, Criselle; Pediongco, Troi J; Cao, Hanwei; Kostenko, Lyudmila; Lim, Xin Yi; Eckle, Sidonia B G; Meehan, Bronwyn S; Zhu, Tianyuan; Wang, Bingjie; Zhao, Zhe; Mak, Jeffrey Y W; Fairlie, David P; Teng, Michele W L; Rossjohn, Jamie; Yu, Di; de St Groth, Barbara Fazekas; Lovrecz, George; Lu, Louis; McCluskey, James; Strugnell, Richard A; Corbett, Alexandra J; Chen, Zhenjun
Science immunology - 1/11/2019
National Health and Medical Research Council of Australia - 1113293
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.
Li, Xian-Yang; Moesta, Achim K; Xiao, Christos; Nakamura, Kyohei; Casey, Mika; Zhang, Haiyan; Madore, Jason; Lepletier, Ailin; Aguilera, Amelia Roman; Sundarrajan, Ashmitha; Jacoberger-Foissac, Celia; Wong, Clifford; Dela Cruz, Tracy; Welch, Megan; Lerner, Alana G; Spatola, Bradley N; Soros, Vanessa B; Corbin, John; Anderson, Ana C; Effern, Maike; Hölzel, Michael; Robson, Simon C; Johnston, Rebecca L; Waddell, Nicola; Smith, Corey; Bald, Tobias; Geetha, Nishamol; Beers, Courtney; Teng, Michele W L; Smyth, Mark J
CANCER DISCOVERY - 1/11/2019
NCI NIH HHS - R21 CA221702
Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23.
Kansara, Maya; Thomson, Kristian; Pang, Puiyi; Dutour, Aurelie; Mirabello, Lisa; Acher, Francine; Pin, Jean-Philippe; Demicco, Elizabeth G; Yan, Juming; Teng, Michele W L; Smyth, Mark J; Thomas, David M
CANCER DISCOVERY - 1/09/2019
National Health and Medical Research Council (NHMRC) - APP1113482
Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model.
Guillerey, Camille; Nakamura, Kyohei; Pichler, Andrea C; Barkauskas, Deborah; Krumeich, Sophie; Stannard, Kimberley; Miles, Kim; Harjunpää, Heidi; Yu, Yuan; Casey, Mika; Doban, Alina I; Lazar, Mircea; Hartel, Gunter; Smith, David; Vuckovic, Slavica; Teng, Michele Wl; Bergsagel, P Leif; Chesi, Marta; Hill, Geoffrey R; Martinet, Ludovic; Smyth, Mark J
JCI INSIGHT - 1/06/2019
Priority-driven Collaborative Cancer Research Scheme grant - Cancer Australia - 1122183
Timing of neoadjuvant immunotherapy in relation to surgery is crucial for outcome
Lio, Jing; O'Donnell, Jake S.; Yan, Juming; Madore, Jason; Allen, Stacey; Smyth, Mark J.; Teng, Michele W. L.
ONCOIMMUNOLOGY - 1/05/2019
National Health and Medical Research Council of Australia (NHMRC) - 1159655
The promise of neoadjuvant immunotherapy and surgery for cancer treatment.
O'Donnell, Jake S; Hoefsmit, Esmee P; Smyth, Mark J; Blank, Christian U; Teng, Michele W L
CLINICAL CANCER RESEARCH - 1/04/2019
The role of NK cells and CD39 in the immunological control of tumor metastases.
Zhang, Haiyan; Vijayan, Dipti; Li, Xian-Yang; Robson, Simon C; Geetha, Nishamol; Teng, Michele W L; Smyth, Mark J
ONCOIMMUNOLOGY - 1/04/2019
National Health and Medical Research Council (NHMRC) - 1078671
CD96 Is an Immune Checkpoint That Regulates CD8 + T-cell Antitumor Function.
Mittal, Deepak; Lepletier, Ailin; Madore, Jason; Aguilera, Amelia Roman; Stannard, Kimberley; Blake, Stephen J; Whitehall, Vicki L J; Liu, Cheng; Bettington, Mark L; Takeda, Kazuyoshi; Long, Georgina V; Scolyer, Richard A; Lan, Ruth; Siemers, Nathan; Korman, Alan; Teng, Michele W L; Johnston, Robert J; Dougall, William C; Smyth, Mark J
Cancer Immunology Research - 1/03/2019
Cancer Research Institute - 6980