Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells
Cobos, Claudia; Bansal, Paramjit S.; Wilson, David T.; Jones, Linda; Zhao, Guangzu; Field, Matthew A.; Eichenberger, Ramon M.; Pickering, Darren A.; Ryan, Rachael Y. M.; Ratnatunga, Champa N.; Miles, John J.; Ruscher, Roland; Giacomin, Paul R.; Navarro, Severine; Loukas, Alex; Daly, Norelle L.
Frontiers In Medicine - 1/01/2022
Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
Smallwood, Taylor B; Navarro, Severine; Cristofori-Armstrong, Ben; Watkins, Thomas S; Tungatt, Katie; Ryan, Rachael Ym; Haigh, Oscar L; Lutzky, Viviana P; Mulvenna, Jason P; Rosengren, K Johan; Loukas, Alex; Miles, John J; Clark, Richard J
Journal of Biological Chemistry - 1/01/2021
Health Challenges of the Pacific Region: Insights From History, Geography, Social Determinants, Genetics, and the Microbiome
Horwood, Paul F.; Tarantola, Arnaud; Goarant, Cyrille; Matsui, Mariko; Klement, Elise; Umezaki, Masahiro; Navarro, Severine; Greenhill, Andrew R.
Frontiers in Immunology - 1/09/2019
Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
Navarro, Severine; Pickering, Darren A.; Ferreira, Ivana B.; Jones, Linda; Ryan, Stephanie; Troy, Sally; Leech, Andrew; Hotez, Peter J.; Zhan, Bin; Laha, Thewarach; Prentice, Roger; Sparwasser, Tim; Croese, John; Engwerda, Christian R.; Upham, John W.; Julia, Valerie; Giacomin, Paul R.; Loukas, Alex
Science Translational Medicine - 1/10/2016
National Health and Medical Research Council of Australia (NHMRC) program - 1037034
Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease
Croese, John; Giacomin, Paul; Navarro, Severine; Clouston, AD; McCann, Leisa; Dougall, Annette; Ferreira, Ivana; Susianto, Atik; O'Rourke, Peter; Howlett, Mariko; McCarthy, James S.; Engwerda, CR; Jones, Dianne M.; Loukas, Alex
The Journal of allergy and clinical immunology - 20/09/2014
Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.
Tribolet, Leon; Cantacessi, Cinzia; Pickering, Darren A.; Navarro, Severine; Doolan, Denise L.; Trieu, Angela; Fei, Huang; Chao, Yang; Hofmann, Andreas; Gasser, Robin B.; Giacomin, Paul R.; Loukas, Alex
J INFECT DIS - 1/08/2014