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NKG7 Is Required for Optimal Antitumor T-cell Immunity.
Li, Xian-Yang; Corvino, Dillon; Nowlan, Bianca; Aguilera, Amelia Roman; Ng, Susanna S; Braun, Matthias; Cillo, Anthony R; Bald, Tobias; Smyth, Mark J; Engwerda, Christian R
Cancer Immunology Research - 1/01/2022
Novel antiinflammatory biologics shaped by parasite-host coevolution
Ryan, Stephanie M.; Ruscher, Roland; Johnston, Wayne A.; Pickering, Darren A.; Kennedy, Malcolm W.; Smith, Brian O.; Jones, Linda; Buitrago, Geraldine; Field, Matt A.; Esterman, Adrian J.; McHugh, Connor P.; Browne, Daniel J.; Cooper, Martha M.; Ryan, Rachael Y. M.; Doolan, Denise L.; Engwerda, Christian R.; Miles, Kim; Mitreva, Makedonka; Croese, John; Rahman, Tony; Alexandrov, Kirill; Giacomin, Paul R.; Loukas, Alex
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 1/01/2022
Increased amphiregulin expression by CD4(+) T cells from individuals with asymptomatic Leishmania donovani infection
Singh, Siddharth Sankar; Chauhan, Shashi Bhushan; Ng, Susanna S. S.; Corvino, Dillon; de Labastida Rivera, Fabian; Engel, Jessica A.; Waddell, Nic; Mukhopadhay, Pamela; Johnston, Rebecca L.; Koufariotis, Lambros T.; Nylen, Susanne; Prakash Singh, Om; Engwerda, Christian R.; Kumar, Rajiv; Sundar, Shyam
Clinical & translational immunology - 1/01/2022
Malaria thriving on steroids.
McConville, Malcolm J; Engwerda, Christian R
Nature metabolism - 1/01/2021
Amphiregulin in cellular physiology, health, and disease: Potential use as a biomarker and therapeutic target.
Singh, Siddharth S; Chauhan, Shashi B; Kumar, Awnish; Kumar, Shashi; Engwerda, Christian R; Sundar, Shyam; Kumar, Rajiv
Journal of cellular physiology - 1/01/2021
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Chughlay, M Farouk; Barnes, Karen I; El Gaaloul, Myriam; Abla, Nada; Möhrle, Jörg J; Griffin, Paul; van Giersbergen, Paul; Reuter, Stephanie E; Schultz, Hayley B; Kress, Anita; Tapley, Peter; Webster, Rebecca A; Wells, Timothy; McCarthy, James S; Barber, Bridget E; Marquart, Louise; Boyle, Michelle J; Engwerda, Christian R; Chalon, Stephan
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY - 1/01/2021
Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.
Webster, Rebecca; Sekuloski, Silvana; Odedra, Anand; Woolley, Stephen; Jennings, Helen; Amante, Fiona; Trenholme, Katharine R; Healer, Julie; Cowman, Alan F; Eriksson, Emily M; Sathe, Priyanka; Penington, Jocelyn; Blanch, Adam J; Dixon, Matthew W A; Tilley, Leann; Duffy, Michael F; Craig, Alister; Storm, Janet; Chan, Jo-Anne; Evans, Krystal; Papenfuss, Anthony T; Schofield, Louis; Griffin, Paul; Barber, Bridget E; Andrew, Dean; Boyle, Michelle J; de Labastida Rivera, Fabian; Engwerda, Christian; McCarthy, James S
BMC MEDICINE - 1/01/2021
Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.
Loughland, Jessica R; Woodberry, Tonia; Oyong, Damian; Piera, Kim A; Amante, Fiona H; Barber, Bridget E; Grigg, Matthew J; William, Timothy; Engwerda, Christian R; Anstey, Nicholas M; McCarthy, James S; Boyle, Michelle J; Minigo, Gabriela
MALARIA JOURNAL - 1/01/2021
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Mills, Richard J; Humphrey, Sean J; Fortuna, Patrick R J; Lor, Mary; Foster, Simon R; Quaife-Ryan, Gregory A; Johnston, Rebecca L; Dumenil, Troy; Bishop, Cameron; Rudraraju, Rajeev; Rawle, Daniel J; Le, Thuy; Zhao, Wei; Lee, Leo; Mackenzie-Kludas, Charley; Mehdiabadi, Neda R; Halliday, Christopher; Gilham, Dean; Fu, Li; Nicholls, Stephen J; Johansson, Jan; Sweeney, Michael; Wong, Norman C W; Kulikowski, Ewelina; Sokolowski, Kamil A; Tse, Brian W C; Devilée, Lynn; Voges, Holly K; Reynolds, Liam T; Krumeich, Sophie; Mathieson, Ellen; Abu-Bonsrah, Dad; Karavendzas, Kathy; Griffen, Brendan; Titmarsh, Drew; Elliott, David A; McMahon, James; Suhrbier, Andreas; Subbarao, Kanta; Porrello, Enzo R; Smyth, Mark J; Engwerda, Christian R; MacDonald, Kelli P A; Bald, Tobias; James, David E; Hudson, James E
CELL - 1/01/2021
Vaccination of human participants with attenuated Necator americanus hookworm larvae and human challenge in Australia: a dose-finding study and randomised, placebo-controlled, phase 1 trial.
Chapman, Paul R; Webster, Rebecca; Giacomin, Paul; Llewellyn, Stacey; Becker, Luke; Pearson, Mark S; De Labastida Rivera, Fabian; O'Rourke, Peter; Engwerda, Christian R; Loukas, Alex; McCarthy, James S
The Lancet. Infectious diseases - 1/01/2021
Transcriptome dynamics of CD4(+) T cells during malaria maps gradual transit from effector to memory
Soon, Megan S. F.; Lee, Hyun Jae; Engel, Jessica A.; Straube, Jasmin; Thomas, Bryce S.; Pernold, Clara P. S.; Clarke, Lachlan S.; Laohamonthonkul, Pawat; Haldar, Rohit N.; Williams, Cameron G.; Lansink, Lianne I. M.; Moreira, Marcela L.; Bramhall, Michael; Koufariotis, Lambros T.; Wood, Scott; Chen, Xi; James, Kylie R.; Lonnberg, Tapio; Lane, Steven W.; Belz, Gabrielle T.; Engwerda, Christian R.; Khoury, David S.; Davenport, Miles P.; Svensson, Valentine; Teichmann, Sarah A.; Haque, Ashraful
NATURE IMMUNOLOGY - 1/10/2020
Australian National Health & Medical Research Council - 1126399
IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection.
Montes de Oca, Marcela; de Labastida Rivera, Fabian; Winterford, Clay; Frame, Teija C M; Ng, Susanna S; Amante, Fiona H; Edwards, Chelsea L; Bukali, Luzia; Wang, Yulin; Uzonna, Jude E; Kuns, Rachel D; Zhang, Ping; Kabat, Agnieszka; Klein Geltink, Ramon I; Pearce, Edward J; Hill, Geoffrey R; Engwerda, Christian R
PLOS PATHOGENS - 1/10/2020
A new era of rational malaria vaccine development.
Engel, Jessica A; Engwerda, Christian R
IMMUNOLOGY AND CELL BIOLOGY - 1/09/2020
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R
NATURE IMMUNOLOGY - 1/08/2020
Department of Health | National Health and Medical Research Council (NHMRC) - 1037304
Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma.
Guillerey, Camille; Stannard, Kimberley; Chen, Jason; Krumeich, Sophie; Miles, Kim; Nakamura, Kyohei; Smith, Jessica; Yu, Yuan; Ng, Susanna; Harjunpää, Heidi; Teng, Michele W L; Engwerda, Christian; Belz, Gabrielle T; Smyth, Mark J
IMMUNOLOGY AND CELL BIOLOGY - 1/08/2020
Cancer Australia - 1122183
Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients.
Singh, Om Prakash; Syn, Genevieve; Nylén, Susanne; Engwerda, Christian; Sacks, David; Wilson, Mary E; Kumar, Rajiv; Chakravarty, Jaya; Sundar, Shyam; Blackwell, Jenefer M; Fakiola, Michaela
The Journal of infectious diseases - 1/07/2020
NIAID NIH HHS - P50 AI074321
Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent Plasmodium falciparum infection.
Loughland, Jessica R; Woodberry, Tonia; Field, Matt; Andrew, Dean W; SheelaNair, Arya; Dooley, Nicholas L; Piera, Kim A; Amante, Fiona H; Kenangalem, Enny; Price, Ric N; Engwerda, Christian R; Anstey, Nicholas M; McCarthy, James S; Boyle, Michelle J; Minigo, Gabriela
Clinical & translational immunology - 1/06/2020
National Health and Medical Research Council (NHMRC) - 1132975
ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome.
Cheong, Melody; Gartlan, Kate H; Lee, Jason S; Tey, Siok-Keen; Zhang, Ping; Kuns, Rachel D; Andoniou, Christopher E; Martins, Jose Paulo; Chang, Karshing; Sutton, Vivien R; Kelly, Greg; Varelias, Antiopi; Vuckovic, Slavica; Markey, Kate A; Boyle, Glen M; Smyth, Mark J; Engwerda, Christian R; MacDonald, Kelli P A; Trapani, Joseph A; Degli-Esposti, Mariapia A; Koyama, Motoko; Hill, Geoffrey R
Cancer Immunology Research - 1/05/2020
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria.
Vijay, Rahul; Guthmiller, Jenna J; Sturtz, Alexandria J; Surette, Fionna A; Rogers, Kai J; Sompallae, Ramakrishna R; Li, Fengyin; Pope, Rosemary L; Chan, Jo-Anne; de Labastida Rivera, Fabian; Andrew, Dean; Webb, Lachlan; Maury, Wendy J; Xue, Hai-Hui; Engwerda, Christian R; McCarthy, James S; Boyle, Michelle J; Butler, Noah S
NATURE IMMUNOLOGY - 1/05/2020
U.S. Department of Veterans Affairs (Department of Veterans Affairs) - BX002903
Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.
Kumar, Rajiv; Bunn, Patrick T; Singh, Siddharth Sankar; Ng, Susanna S; Montes de Oca, Marcela; De Labastida Rivera, Fabian; Chauhan, Shashi Bhushan; Singh, Neetu; Faleiro, Rebecca J; Edwards, Chelsea L; Frame, Teija C M; Sheel, Meru; Austin, Rebecca J; Lane, Steven W; Bald, Tobias; Smyth, Mark J; Hill, Geoffrey R; Best, Shannon E; Haque, Ashraful; Corvino, Dillon; Waddell, Nic; Koufariotis, Lambross; Mukhopadhay, Pamela; Rai, Madhukar; Chakravarty, Jaya; Singh, Om Prakash; Sacks, David; Nylen, Susanne; Uzonna, Jude; Sundar, Shyam; Engwerda, Christian R
Cell Reports - 1/02/2020
NIH Tropical Medicine Research Centers (TMRC) grant - U19 AI074321