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Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma
Allam, Venkata Sita Rama Raju; Pavlidis, Stelios; Liu, Gang; Kermani, Nazanin Zounemat; Simpson, Jennifer; To, Joyce; Donnelly, Sheila; Guo, Yi-Ke; Hansbro, Philip M.; Phipps, Simon; Morand, Eric F.; Djukanovic, Ratko; Sterk, Peter; Chung, Kian Fan; Adcock, Ian; Harris, James; Sukkar, Maria B.
THORAX - 1/01/2022
Synergism and Antagonism of Bacterial-Viral Coinfection in the Upper Respiratory Tract.
Manna, Sam; McAuley, Julie; Jacobson, Jonathan; Nguyen, Cattram D; Ullah, Md Ashik; Sebina, Ismail; Williamson, Victoria; Mulholland, E Kim; Wijburg, Odilia; Phipps, Simon; Satzke, Catherine
MSPHERE - 1/01/2022
IFN-? Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Sebina, Ismail; Rashid, Ridwan B; Sikder, Md Al Amin; Rahman, Muhammed Mahfuzur; Ahmed, Tufael; Radford-Smith, Daniel E; Kotenko, Sergei V; Hill, Geoffrey R; Bald, Tobias; Phipps, Simon
Journal of immunology (Baltimore, Md. : 1950) - 1/01/2022
MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells.
Simpson, Jennifer; Spann, Kirsten M; Phipps, Simon
Frontiers in cell and developmental biology - 1/01/2022
Eosinophils apply a handbrake to plasmacytoid dendritic cell antiviral immunity in asthma.
Phipps, Simon; Howard, Daniel Ryan; Werder, Rhiannon Bree
The Journal of allergy and clinical immunology - 1/01/2022
Author Correction: Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Tu, Wen Juan; McCuaig, Robert D; Melino, Michelle; Rawle, Daniel J; Le, Thuy T; Yan, Kexin; Suhrbier, Andreas; Johnston, Rebecca L; Koufariotis, Lambros T; Waddell, Nicola; Cross, Emily M; Tsimbalyuk, Sofiya; Bain, Amanda; Ahern, Elizabeth; Collinson, Natasha; Phipps, Simon; Forwood, Jade K; Seddiki, Nabila; Rao, Sudha
Cell discovery - 1/01/2021
The maternal gut microbiome during pregnancy and offspring allergy and asthma.
Gao, Yuan; Nanan, Ralph; Macia, Laurence; Tan, Jian; Sominsky, Luba; Quinn, Thomas P; O'Hely, Martin; Ponsonby, Anne-Louise; Tang, Mimi Lk; Collier, Fiona; Strickland, Deborah H; Dhar, Poshmaal; Brix, Susanne; Phipps, Simon; Sly, Peter D; Ranganathan, Sarath; Stokholm, Jakob; Kristiansen, Karsten; Gray, Lawrence; Vuillermin, Peter
The Journal of allergy and clinical immunology - 1/01/2021
Bone Marrow Regulatory T Cells Are a Unique Population, Supported by Niche-Specific Cytokines and Plasmacytoid Dendritic Cells, and Required for Chronic Graft-Versus-Host Disease Control.
Nicholls, Jemma; Cao, Benjamin; Le Texier, Laetitia; Xiong, Laura Yan; Hunter, Christopher R; Llanes, Genesis; Aguliar, Ethan G; Schroder, Wayne A; Phipps, Simon; Lynch, Jason P; Cao, Huimin; Heazlewood, Shen Y; Williams, Brenda; Clouston, Andrew D; Nefzger, Christian M; Polo, Jose M; Nilsson, Susan K; Blazar, Bruce R; MacDonald, Kelli P A
Frontiers in cell and developmental biology - 1/01/2021
Modulation of Vagal Sensory Neurons via High Mobility Group Box-1 and Receptor for Advanced Glycation End Products: Implications for Respiratory Viral Infections.
Mazzone, Stuart B; Yang, Seung-Kwon; Keller, Jennifer A; Simanauskaite, Juste; Arikkatt, Jaisy; Fogarty, Matthew J; Moe, Aung Aung Kywe; Chen, Chen; Trewella, Matthew W; Tian, Luyi; Ritchie, Matthew E; Chua, Brendan Y; Phipps, Simon; Short, Kirsty R; McGovern, Alice E
Frontiers In Physiology - 1/01/2021
A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants.
Hulme, Katina D; Karawita, Anjana C; Pegg, Cassandra; Bunte, Myrna Jm; Bielefeldt-Ohmann, Helle; Bloxham, Conor J; Van den Hoecke, Silvie; Setoh, Yin Xiang; Vrancken, Bram; Spronken, Monique; Steele, Lauren E; Verzele, Nathalie Aj; Upton, Kyle R; Khromykh, Alexander A; Chew, Keng Yih; Sukkar, Maria; Phipps, Simon; Short, Kirsty R
Elife - 1/01/2021
LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE.
Pouwels, Simon D; Hesse, Laura; Wu, Xinhui; Allam, Venkata Sita Rama Raju; van Oldeniel, Daan; Bhiekharie, Linsey J; Phipps, Simon; Oliver, Brian G G; Gosens, Reinoud; Sukkar, Maria; Heijink, Irene H
American journal of physiology. Lung cellular and molecular physiology - 1/01/2021
Increased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis.
Maniam, Pramila; Essilfie, Ama-Tawiah; Kalimutho, Murugan; Ling, Dora; Frazer, David M; Phipps, Simon; Anderson, Gregory J; Reid, David W
Biological research - 1/01/2021
Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Werder, Rhiannon B; Ullah, Md Ashik; Rahman, Muhammed Mahfuzur; Simpson, Jennifer; Lynch, Jason P; Collinson, Natasha; Rittchen, Sonja; Rashid, Ridwan B; Sikder, Md Al Amin; Handoko, Herlina Y; Curren, Bodie F; Sebina, Ismail; Hartel, Gunter; Bissell, Alec; Ngo, Sylvia; Yarlagadda, Tejasri; Hasnain, Sumaira Z; Lu, Wenying; Sohal, Sukhwinder S; Martin, Megan; Bowler, Simon; Burr, Lucy D; Martinez, Laurent O; Robaye, Bernard; Spann, Kirsten; Ferreira, Manuel A R; Phipps, Simon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE - 1/01/2021
DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-a-induced immunopathology.
Ullah, Md Ashik; Rittchen, Sonja; Li, Jia; Hasnain, Sumaira Z; Phipps, Simon
Mucosal Immunology - 1/01/2021
Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Tu, Wen Juan; McCuaig, Robert D; Melino, Michelle; Rawle, Daniel J; Le, Thuy T; Yan, Kexin; Suhrbier, Andreas; Johnston, Rebecca L; Koufariotis, Lambros T; Waddell, Nicola; Cross, Emily M; Tsimbalyuk, Sofiya; Bain, Amanda; Ahern, Elizabeth; Collinson, Natasha; Phipps, Simon; Forwood, Jade K; Seddiki, Nabila; Rao, Sudha
Cell discovery - 1/01/2021
RAGE and TLR4 differentially regulate airway hyperresponsiveness: implications for COPD.
Allam, Venkata Sita Rama Raju; Faiz, Alen; Lam, Maggie; Rathnayake, Senani N H; Ditz, Benedikt; Pouwels, Simon D; Brandsma, Corry-Anke; Timens, Wim; Hiemstra, Pieter S; Tew, Gaik W; Neighbors, Maggie; Grimbaldeston, Michele; van den Berge, Maarten; Donnelly, Sheila; Phipps, Simon; Bourke, Jane E; Sukkar, Maria B
ALLERGY - 1/08/2020
HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling.
Loh, Zhixuan; Simpson, Jennifer; Ullah, Ashik; Zhang, Vivian; Gan, Wan J; Lynch, Jason P; Werder, Rhiannon B; Sikder, Al Amin; Lane, Katie; Sim, Choon Boon; Porrello, Enzo; Mazzone, Stuart B; Sly, Peter D; Steptoe, Raymond J; Spann, Kirsten M; Sukkar, Maria B; Upham, John W; Phipps, Simon
PLOS PATHOGENS - 1/07/2020
NHMRC - ID1023756
The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis.
Sebina, Ismail; Phipps, Simon
Viruses - 1/07/2020
National Health and Medical Research Council - 1141581
RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.
Simpson, Jennifer; Loh, Zhixuan; Ullah, Md Ashik; Lynch, Jason P; Werder, Rhiannon B; Collinson, Natasha; Zhang, Vivian; Dondelinger, Yves; Bertrand, Mathieu J M; Everard, Mark L; Blyth, Christopher C; Hartel, Gunter; Van Oosterhout, Antoon J; Gough, Peter J; Bertin, John; Upham, John W; Spann, Kirsten M; Phipps, Simon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE - 1/02/2020
Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma.
Lynch, Jason P; Werder, Rhiannon B; Curren, Bodie F; Sikder, Md Al Amin; Ullah, Ashik; Sebina, Ismail; Rashid, Ridwan B; Zhang, Vivian; Upham, John W; Hill, Geoff R; Steptoe, Raymond J; Phipps, Simon
Mucosal Immunology - 1/02/2020