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Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer.
Saunus, Jodi M; De Luca, Xavier M; Northwood, Korinne; Raghavendra, Ashwini; Hasson, Alexander; McCart Reed, Amy E; Lim, Malcolm; Lal, Samir; Vargas, A Cristina; Kutasovic, Jamie R; Dalley, Andrew J; Miranda, Mariska; Kalaw, Emarene; Kalita-de Croft, Priyakshi; Gresshoff, Irma; Al-Ejeh, Fares; Gee, Julia M W; Ormandy, Chris; Khanna, Kum Kum; Beesley, Jonathan; Chenevix-Trench, Georgia; Green, Andrew R; Rakha, Emad A; Ellis, Ian O; Nicolau, Dan V; Simpson, Peter T; Lakhani, Sunil R
NPJ BREAST CANCER - 1/01/2022
hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
Boucher, Didier; Kariawasam, Ruvini; Burgess, Joshua; Gimenez, Adrian; Ocampo, Tristan E; Ferguson, Blake; Naqi, Ali; Walker, Graeme J; Bolderson, Emma; Gamsjaeger, Roland; O'Byrne, Kenneth J; Cubeddu, Liza; Khanna, Kum Kum; Richard, Derek J
SCIENTIFIC REPORTS - 1/01/2021
WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.
Ho, Uda Y; Feng, Chun-Wei Allen; Yeap, Yvonne Y; Bain, Amanda L; Wei, Zhe; Shohayeb, Belal; Reichelt, Melissa E; Homer, Hayden; Khanna, Kum Kum; Bowles, Josephine; Ng, Dominic C H
Communications Biology - 1/01/2021
CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer.
Makhale, Ashwini; Nanayakkara, Devathri; Raninga, Prahlad; Khanna, Kum Kum; Kalimutho, Murugan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 1/01/2021
Targeting BRF2 in Cancer Using Repurposed Drugs.
Rashidieh, Behnam; Molakarimi, Maryam; Mohseni, Ammar; Tria, Simon Manuel; Truong, Hein; Srihari, Sriganesh; Adams, Rachael C; Jones, Mathew; Duijf, Pascal H G; Kalimutho, Murugan; Khanna, Kum Kum
Cancers - 1/01/2021
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
Rashidieh, Behnam; Shohayeb, Belal; Bain, Amanda Louise; Fortuna, Patrick R J; Sinha, Debottam; Burgess, Andrew; Mills, Richard; Adams, Rachael C; Lopez, J Alejandro; Blumbergs, Peter; Finnie, John; Kalimutho, Murugan; Piper, Michael; Hudson, James Edward; Ng, Dominic C H; Khanna, Kum Kum
PLOS GENETICS - 1/01/2021
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response.
McMahon, Kerrie-Ann; Stroud, David A; Gambin, Yann; Tillu, Vikas; Bastiani, Michele; Sierecki, Emma; Polinkovsky, Mark E; Hall, Thomas E; Gomez, Guillermo A; Wu, Yeping; Parat, Marie-Odile; Martel, Nick; Lo, Harriet P; Khanna, Kum Kum; Alexandrov, Kirill; Daly, Roger; Yap, Alpha; Ryan, Michael T; Parton, Robert G
Elife - 1/01/2021
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Sinha, Debottam; Nag, Purba; Nanayakkara, Devathri; Duijf, Pascal H G; Burgess, Andrew; Raninga, Prahlad; Smits, Veronique A J; Bain, Amanda L; Subramanian, Goutham; Wall, Meaghan; Finnie, John W; Kalimutho, Murugan; Khanna, Kum Kum
Communications Biology - 1/10/2020
Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer.
Sanij, Elaine; Hannan, Katherine; Xuan, Jiachen; Yan, Shunfei; Ahern, Jessica A.; Trigos, Anna S.; Brajanovski, Natalie; Son, Jinbae; Chan, Keefe T.; Kondrashova, Olga; Lieschke, Elizabeth; Wakefield, Matthew J.; Ellis, Sarah; Cullinane, Carleen; Poortinga, Gretchen; Khanna, Kum Kum; Mileshkin, Linda; McArthur, Grant A.; Soong, John; Berns, Els M.; Hannan, Ross D.; Scott, Clare L.; Sheppard, Karen E.; Pearson, Richard B.
CLINICAL CANCER RESEARCH - 1/07/2020
RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
Kim, Seong-Jin; Ju, Jin-Sung; Kang, Myoung-Hee; Eun, Ji Won; Kim, Young Ha; Raninga, Prahlad V; Khanna, Kum Kum; Gyorffy, Balázs; Pack, Chan-Gi; Han, Hee-Dong; Lee, Hee Jin; Gong, Gyungyub; Shin, Yong; Mills, Gordon B; Eyun, Seong-Il; Park, Yun-Yong
THERANOSTICS - 1/07/2020
Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea - HI17C0380
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.
Sanij, Elaine; Hannan, Katherine M; Xuan, Jiachen; Yan, Shunfei; Ahern, Jessica E; Trigos, Anna S; Brajanovski, Natalie; Son, Jinbae; Chan, Keefe T; Kondrashova, Olga; Lieschke, Elizabeth; Wakefield, Matthew J; Frank, Daniel; Ellis, Sarah; Cullinane, Carleen; Kang, Jian; Poortinga, Gretchen; Nag, Purba; Deans, Andrew J; Khanna, Kum Kum; Mileshkin, Linda; McArthur, Grant A; Soong, John; Berns, Els M J J; Hannan, Ross D; Scott, Clare L; Sheppard, Karen E; Pearson, Richard B
Nature Communications - 1/05/2020
Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition
Raninga, Prahlad; Lee, Andy; Sinha, Debottam; Dong, Lan-feng; Datta, Keshava; Lu, Xue; Kalita-de Croft, Priyakshi; Dutt, Mriga; Hill, Michelle M.; Pouliot, Normand M.; Gowda, Harsha; Kalimutho, Murugan; Neuzil, Jiri; Khanna, Kum Kum
THERANOSTICS - 1/01/2020
Chromosome arm aneuploidies shape tumour evolution and drug response.
Shukla, Ankit; Nguyen, Thu H M; Moka, Sarat B; Ellis, Jonathan J; Grady, John P; Oey, Harald; Cristino, Alexandre S; Khanna, Kum Kum; Kroese, Dirk P; Krause, Lutz; Dray, Eloise; Fink, J Lynn; Duijf, Pascal H G
Nature Communications - 1/01/2020
Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether Ionophore.
Lim, Yi Chieh; Ensbey, Kathleen S; Offenhäuser, Carolin; D'Souza, Rochelle C J; Cullen, Jason K; Stringer, Brett W; Quek, Hazel; Bruce, Zara C; Kijas, Amanda; Cianfanelli, Valentina; Mahboubi, Bijan; Smith, Fiona; Jeffree, Rosalind L; Wiesmüeller, Lisa; Wiegmans, Adrian P; Bain, Amanda; Lombard, Fanny J; Roberts, Tara L; Khanna, Kum Kum; Lavin, Martin F; Baek, Kim; Hamerlik, Petra; Johns, Terrance G; Coster, Mark J; Boyd, Andrew W; Day, Bryan W
NEURO-ONCOLOGY - 1/08/2019
Cancer Council Qld - 1061216
First meiotic anaphase requires Cep55-dependent inhibitory Cdk1 phosphorylation.
Zhou, Chenxi; Hancock, Janelle L; Khanna, Kum Kum; Homer, Hayden A
Journal of cell science - 1/08/2019
Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.
Sze, Jun Hui; Raninga, Prahlad V; Nakamura, Kyohei; Casey, Mika; Khanna, Kum Kum; Berners-Price, Susan J; Di Trapani, Giovanna; Tonissen, Kathryn F
REDOX BIOLOGY - 1/08/2019
GSK3-ß Stimulates Claspin Degradation via ß-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival.
Cabrera, Elisa; Raninga, Prahlad; Khanna, Kum Kum; Freire, Raimundo
Cancers - 1/07/2019
Spanish Ministry of Innovation Science and Universities - SAF2016-80626-R , BFU2016-81796-REDC
A Comprehensive Review on Current Advances in Peptide Drug Development and Design.
Lee, Andy Chi-Lung; Harris, Janelle Louise; Khanna, Kum Kum; Hong, Ji-Hong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 1/05/2019
Chang Gung Memorial Hospital - CMRPG3F2232, CMRP3G1491, CMRPG3H1241