NKG7 Is Required for Optimal Antitumor T-cell Immunity.
Li, Xian-Yang; Corvino, Dillon; Nowlan, Bianca; Aguilera, Amelia Roman; Ng, Susanna S; Braun, Matthias; Cillo, Anthony R; Bald, Tobias; Smyth, Mark J; Engwerda, Christian R
Cancer Immunology Research - 1/01/2022
IFN-? Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Sebina, Ismail; Rashid, Ridwan B; Sikder, Md Al Amin; Rahman, Muhammed Mahfuzur; Ahmed, Tufael; Radford-Smith, Daniel E; Kotenko, Sergei V; Hill, Geoffrey R; Bald, Tobias; Phipps, Simon
Journal of immunology (Baltimore, Md. : 1950) - 1/01/2022
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Mills, Richard J; Humphrey, Sean J; Fortuna, Patrick R J; Lor, Mary; Foster, Simon R; Quaife-Ryan, Gregory A; Johnston, Rebecca L; Dumenil, Troy; Bishop, Cameron; Rudraraju, Rajeev; Rawle, Daniel J; Le, Thuy; Zhao, Wei; Lee, Leo; Mackenzie-Kludas, Charley; Mehdiabadi, Neda R; Halliday, Christopher; Gilham, Dean; Fu, Li; Nicholls, Stephen J; Johansson, Jan; Sweeney, Michael; Wong, Norman C W; Kulikowski, Ewelina; Sokolowski, Kamil A; Tse, Brian W C; Devilée, Lynn; Voges, Holly K; Reynolds, Liam T; Krumeich, Sophie; Mathieson, Ellen; Abu-Bonsrah, Dad; Karavendzas, Kathy; Griffen, Brendan; Titmarsh, Drew; Elliott, David A; McMahon, James; Suhrbier, Andreas; Subbarao, Kanta; Porrello, Enzo R; Smyth, Mark J; Engwerda, Christian R; MacDonald, Kelli P A; Bald, Tobias; James, David E; Hudson, James E
CELL - 1/01/2021
Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy.
Weulersse, Marianne; Asrir, Assia; Pichler, Andrea C; Lemaitre, Lea; Braun, Matthias; Carrié, Nadège; Joubert, Marie-Véronique; Le Moine, Marie; Do Souto, Laura; Gaud, Guillaume; Das, Indrajit; Brauns, Elisa; Scarlata, Clara M; Morandi, Elena; Sundarrajan, Ashmitha; Cuisinier, Marine; Buisson, Laure; Maheo, Sabrina; Kassem, Sahar; Agesta, Arantxa; Pérès, Michaël; Verhoeyen, Els; Martinez, Alejandra; Mazieres, Julien; Dupré, Loïc; Gossye, Thomas; Pancaldi, Vera; Guillerey, Camille; Ayyoub, Maha; Dejean, Anne S; Saoudi, Abdelhadi; Goriely, Stanislas; Avet-Loiseau, Hervé; Bald, Tobias; Smyth, Mark J; Martinet, Ludovic
IMMUNITY - 1/10/2020
Fondation ARC - PGA1-20160203788
CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.
Braun, Matthias; Aguilera, Amelia Roman; Sundarrajan, Ashmitha; Corvino, Dillon; Stannard, Kimberley; Krumeich, Sophie; Das, Indrajit; Lima, Luize G; Meza Guzman, Lizeth G; Li, Kunlun; Li, Rui; Salim, Nazhifah; Jorge, Maria Villancanas; Ham, Sunyoung; Kelly, Gabrielle; Vari, Frank; Lepletier, Ailin; Raghavendra, Ashwini; Pearson, Sally; Madore, Jason; Jacquelin, Sebastien; Effern, Maike; Quine, Brodie; Koufariotis, Lambros T; Casey, Mika; Nakamura, Kyohei; Seo, Eun Y; Hölzel, Michael; Geyer, Matthias; Kristiansen, Glen; Taheri, Touraj; Ahern, Elizabeth; Hughes, Brett G M; Wilmott, James S; Long, Georgina V; Scolyer, Richard A; Batstone, Martin D; Landsberg, Jennifer; Dietrich, Dimo; Pop, Oltin T; Flatz, Lukas; Dougall, William C; Veillette, André; Nicholson, Sandra E; Möller, Andreas; Johnston, Robert J; Martinet, Ludovic; Smyth, Mark J; Bald, Tobias
IMMUNITY - 1/10/2020
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R
NATURE IMMUNOLOGY - 1/08/2020
Department of Health | National Health and Medical Research Council (NHMRC) - 1037304
Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma.
Effern, Maike; Glodde, Nicole; Braun, Matthias; Liebing, Jana; Boll, Helena N; Yong, Michelle; Bawden, Emma; Hinze, Daniel; van den Boorn-Konijnenberg, Debby; Daoud, Mila; Aymans, Pia; Landsberg, Jennifer; Smyth, Mark J; Flatz, Lukas; Tüting, Thomas; Bald, Tobias; Gebhardt, Thomas; Hölzel, Michael
IMMUNITY - 1/07/2020
NHMRC Early Career Fellowship - 1124690
Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma.
Lepletier, Ailin; Madore, Jason; O'Donnell, Jake S; Johnston, Rebecca L; Li, Xian-Yang; McDonald, Elizabeth; Ahern, Elizabeth; Kuchel, Anna; Eastgate, Melissa; Pearson, Sally-Ann; Mallardo, Domenico; Ascierto, Paolo A; Massi, Daniela; Merelli, Barbara; Mandala, Mario; Wilmott, James S; Menzies, Alexander M; Leduc, Charles; Stagg, John; Routy, Bertrand; Long, Georgina V; Scolyer, Richard A; Bald, Tobias; Waddell, Nicola; Dougall, William C; Teng, Michele W L; Smyth, Mark J
CLINICAL CANCER RESEARCH - 1/04/2020
Innate Cancer Immunoediting.
Bald, Tobias; Smyth, Mark J
Journal of Investigative Dermatology - 1/04/2020
NH&MRC early career fellowship - 1124690
Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.
Kumar, Rajiv; Bunn, Patrick T; Singh, Siddharth Sankar; Ng, Susanna S; Montes de Oca, Marcela; De Labastida Rivera, Fabian; Chauhan, Shashi Bhushan; Singh, Neetu; Faleiro, Rebecca J; Edwards, Chelsea L; Frame, Teija C M; Sheel, Meru; Austin, Rebecca J; Lane, Steven W; Bald, Tobias; Smyth, Mark J; Hill, Geoffrey R; Best, Shannon E; Haque, Ashraful; Corvino, Dillon; Waddell, Nic; Koufariotis, Lambross; Mukhopadhay, Pamela; Rai, Madhukar; Chakravarty, Jaya; Singh, Om Prakash; Sacks, David; Nylen, Susanne; Uzonna, Jude; Sundar, Shyam; Engwerda, Christian R
Cell Reports - 1/02/2020
NIH Tropical Medicine Research Centers (TMRC) grant - U19 AI074321
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.
Li, Xian-Yang; Moesta, Achim K; Xiao, Christos; Nakamura, Kyohei; Casey, Mika; Zhang, Haiyan; Madore, Jason; Lepletier, Ailin; Aguilera, Amelia Roman; Sundarrajan, Ashmitha; Jacoberger-Foissac, Celia; Wong, Clifford; Dela Cruz, Tracy; Welch, Megan; Lerner, Alana G; Spatola, Bradley N; Soros, Vanessa B; Corbin, John; Anderson, Ana C; Effern, Maike; Hölzel, Michael; Robson, Simon C; Johnston, Rebecca L; Waddell, Nicola; Smith, Corey; Bald, Tobias; Geetha, Nishamol; Beers, Courtney; Teng, Michele W L; Smyth, Mark J
CANCER DISCOVERY - 1/11/2019
NCI NIH HHS - R21 CA221702
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
Glodde, Nicole; Bald, Tobias; van den Boorn-Konijnenberg, Debby; Nakamura, Kyohei; O'Donnell, Jake S.; Szczepanski, Sabrina; Brandes, Maria; Eickhoff, Sarah; Das, Indrajit; Shridhar, Naveen; Hinze, Daniel; Rogava, Meri; van der Sluis, Tetje C.; Ruotsalainen, Janne J.; Gaffal, Evelyn; Landsberg, Jennifer; Ludwig, Kerstin U.; Wilhelm, Christoph; Riek-Burchardt, Monika; Mueller, Andreas J.; Gebhardt, Christoffer; Scolyer, Richard A.; Long, Georgina V.; Janzen, Viktor; Teng, Michele W. L.; Kastenmueller, Wolfgang; Mazzone, Massimiliano; Smyth, Mark J.; Tueting, Thomas; Hoelzel, Michael
IMMUNITY - 1/10/2017
DFG-INST - 217/674-1 FUGG
MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy
Reinhardt, Julia; Landsberg, Jennifer; Schmid-Burgk, Jonathan L.; Ramis, Bartomeu Bibiloni; Bald, Tobias; Glodde, Nicole; Lopez-Ramos, Dorys; Young, Arabella; Ngiow, Shin Foong; Nettersheim, Daniel; Schorle, Hubert; Quast, Thomas; Kolanus, Waldemar; Schadendorf, Dirk; Long, Georgina V.; Madore, Jason; Scolyer, Richard A.; Ribas, Antoni; Smyth, Mark J.; Tumeh, Paul C.; Tueting, Thomas; Hoelzel, Michael
CANCER RESEARCH - 1/09/2017
National Health and Medical Research Council of Australia (NHMRC) - 1078671
Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis
Young, Arabella; Ngiow, Shin Foong; Madore, Jason; Reinhardt, Julia; Landsberg, Jennifer; Chitsazan, Arash; Rautela, Jai; Bald, Tobias; Barkauskas, Deborah S.; Ahern, Elizabeth; Huntington, Nicholas D.; Schadendorf, Dirk; Long, Georgina V.; Boyle, Glen M.; Hoelzel, Michael; Scolyer, Richard A.; Smyth, Mark J.
CANCER RESEARCH - 1/09/2017
National Health and Medical Research Council of Australia (NHMRC) Senior Research Fellowship - 1078671
Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
Gao, Yulong; Souza-Fonseca-Guimaraes, Fernando; Bald, Tobias; Ng, Susanna S.; Young, Arabella; Ngiow, Shin Foong; Rautela, Jai; Straube, Jasmin; Waddell, Nic; Blake, Stephen J.; Yan, Juming; Bartholin, Laurent; Lee, Jason S.; Vivier, Eric; Takeda, Kazuyoshi; Messaoudene, Meriem; Zitvogel-, Laurence; Teng, Michele W. L.; Belz, Gabrielle T.; Engwerda, Christian R.; Huntington, Nicholas D.; Nakamura, Kyohei; Hoelzel, Michael; Smyth, Mark J.
NATURE IMMUNOLOGY - 1/09/2017
National Health and Medical Research Council of Australia - 1078671
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization
van der Weyden, Louise; Arends, Mark J.; Campbell, Andrew D.; Bald, Tobias; Wardle-Jones, Hannah; Griggs, Nicola; Velasco-Herrera, Martin del Castillo; Tuting, Thomas; Sansom, Owen J. .; Karp, Natasha A. .; Clare, Simon; Gleeson, Diane; Ryder, Edward; Galli, Antonella; Tuck, Elizabeth; Cambridge, Emma L.; Voet, Thierry; Macaulay, Iain C.; Wong, Kim; Spiegel, Sarah; Speak, Anneliese O.; Adams, David J.
NATURE - 1/01/2017
