Vitamin D plays an important role in calcium homeostasis and many cellular processes. Although vitamin D supplements are widely recommended for community-dwelling adults, definitive data on whether these supplements benefit clinically important skeletal and extraskeletal outcomes have been conflicting. Although observational studies on effects of vitamin D on musculoskeletal and extraskeletal outcomes may be confounded by reverse causation, randomized controlled studies (RCTs) and Mendelian randomization (MR) studies can help to elucidate causation. In this review, we summarize the recent findings from large RCTs and/or MR studies of vitamin D on bone health and risk of fractures, falls, cancer, and cardiovascular disease, disorders of the immune system, multiple sclerosis, and mortality in community-dwelling adults. The primary analyses indicate that vitamin D supplementation does not decrease bone loss, fractures, falls, cancer incidence, hypertension, or cardiovascular risk in gener...
| Authors | Bouillon, R; LeBoff, MS; Neale, RE |
|---|---|
| Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research |
| Pages | 1391-1403 |
| Volume | 38 |
| Date | 10/09/2023 |
| Grant ID | R01 AT011729 | NCCIH NIH HHS [AT] (United States); R01 CA138962 | NCI NIH HHS [CA] (United States); R01 AR059775 | NIAMS NIH HHS [AR] (United States); U01 CA138962 | NCI NIH HHS [CA] (United States); UL1 RR025758 | NCRR NIH HHS [RR] (United States); R01 AR060574 | NIAMS NIH HHS [AR] (United States); R01 AR070854 | NIAMS NIH HHS [AR] (United States); UL1 TR000170 | NCATS NIH HHS [TR] (United States); UL1 TR001102 | NCATS NIH HHS [TR] (United States) |
| Funding Body | |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/jbmr.4888 |