Infection by high-risk human papillomavirus is known to exacerbate cervical cancer development. The host immune response is crucial in disease regression. Large-scale genetic association studies for cervical cancer have identified few susceptibility variants, mainly at the human leukocyte antigen locus on chromosome 6. We hypothesized that the host immune response modifies cervical cancer risk and performed three genome-wide association analyses for HPV16, HPV18 and HPV16/18 seropositivity in 7814, 7924, and 7924 samples from the UK Biobank, followed by validation genotyping in the German Cervigen case-control series of cervical cancer and dysplasia. In GWAS analyses, we identified two loci associated with HPV16 seropositivity (6p21.32 and 15q26.2), two loci associated with HPV18 seropositivity (5q31.2 and 14q24.3), and one locus for HPV16 and/or HPV18 seropositivity (at 6p21.32). MAGMA gene-based analysis identified HLA-DQA1 and HLA-DQB1 as genome-wide significant (GWS) genes. In vali...
| Authors | Beckhaus, T; Kachuri, L; Nakase, T; Schürmann, P; Eisenblätter, R; Geerts, M; Böhmer, G; Strauß, HG; Hirchenhain, C; Schmidmayr, M; Müller, F; Fasching, PA; Häfner, N; Luyten, A; Jentschke, M; Hillemanns, P; O'Mara, TA; Francis, SS; Witte, JS; Dörk, T; Ramachandran, D |
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| Journal | JOURNAL OF MEDICAL VIROLOGY |
| Pages | e70195 |
| Volume | 97 |
| Date | 1/02/2025 |
| Grant ID | D.R. and T.D. received funding from the H.W. & J. Hector Stiftung (M2414). D.R. received funding from the Tumorstiftung at Hannover Medical School. M.G. received a stipend from the University of British Columbia. The Cervigen consortium was established with funding from the Bruno and Helene Jöster Foundation. |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/jmv.70195 |