Abstract

With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), are predominant. Retinol, a vitamin A derivative, is essential in the regulation of growth and differentiation of epidermal cells. Moreover, retinol exhibits antioxidant properties, protecting the skin against ultra-violet (UV) radiation induced oxidative damage. Existing research on the impact of retinol on melanoma, SCC and BCC development shows mixed results. Several dietary intake studies have suggested that higher retinol levels reduce skin cancer risk, however, others have failed to find this association. We used two-sample Mendelian randomization (MR) to explore if there is a causal relationship between retinol and the risk of developing melanoma, SCC or BCC. Genetically predicted circulating retinol levels were obtained from a genome wide as...

Authors	Helder, M; Pandeya, N; Seviiri, M; Olsen, CM; Whiteman, DC; Law, MH
Journal	medRxiv : the preprint server for health sciences
Pages
Volume
Date	28/09/2024
Grant ID	Wellcome Trust [WT_] (United Kingdom); R01 CA083115 | NCI NIH HHS [CA] (United States)
Funding Body
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1101/2024.08.27.24312670