Abstract

To evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic review and meta-analysis of randomised, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted. Overall, 14 RCTs with a total of 104,727 participants (2015 cancer deaths) were identified and 7 RCTs, including 90 % of all study participants (n = 94,068), could be included in the IPD meta-analyses. The main meta-analysis of the 14 RCTs yielded a statistically non-significant reduction in cancer mortality by 6 % (risk ratio (RR) [95%-confidence interval (95%CI)]: 0.94 [0.86-1.02]). Subgroup analyses revealed a 12 % lower cancer mortality in the vitamin D3 group compared with the placebo group in 10 trials with a daily dosing regimen (RR [95%CI]: 0.88 [0.78-0.98]), whereas no mortality reduction was seen in 4 trials using a bolus regimen (RR [95%CI]: 1.07 [0.91-1.24]; p-value for interaction: 0.042). The IPD meta-anal...

Authors	Kuznia, S; Zhu, A; Akutsu, T; Buring, JE; Camargo, CA; Cook, NR; Chen, LJ; Cheng, TD; Hantunen, S; Lee, IM; Manson, JE; Neale, RE; Scragg, R; Shadyab, AH; Sha, S; Sluyter, J; Tuomainen, TP; Urashima, M; Virtanen, JK; Voutilainen, A; Wactawski-Wende, J; Waterhouse, M; Brenner, H; Schöttker, B
Journal	Ageing research reviews
Pages	101923
Volume	87
Date	1/04/2023
Grant ID	75N92021D00002 | NHLBI NIH HHS [HL] (United States); R01 AT011729 | NCCIH NIH HHS [AT] (United States); 75N92021D00001 | NHLBI NIH HHS [HL] (United States); 75N92021D00003 | WHI NIH HHS [WH] (United States); 75N92021D00004 | WHI NIH HHS [WH] (United States); 75N92021D00005 | WHI NIH HHS [WH] (United States); R01 CA138962 | NCI NIH HHS [CA] (United States); U01 CA138962 | NCI NIH HHS [CA] (United States); G9706483 | Medical Research Council [MRC_] (United Kingdom)
Funding Body
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.arr.2023.101923