Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model

Abstract

An adult wild-type C57BL/6J mouse model of chikungunya virus (CHIKV) infection and disease has been extensively used to study the alphaviral arthritic immunopathology and to evaluate new interventions. How well mouse models recapitulate the gene expression profiles seen in humans remains controversial.

Authors Bishop, CR; Caten, FT; Nakaya, HI; Suhrbier, A
Journal Frontiers in Immunology
Pages
Volume 13
Date 12/01/2022
Grant ID
Funding Body
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3389/fimmu.2022.1092370