The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the pharmacological interaction of this antimalarial combination in a volunteer infection study (VIS) would have enabled prediction of the phase 2b study results.
| Authors | Abd-Rahman, AN; Kaschek, D; Kümmel, A; Webster, R; Potter, AJ; Odedra, A; Woolley, SD; Llewellyn, S; Webb, L; Marquart, L; Chalon, S; Gaaloul, ME; McCarthy, JS; Möhrle, JJ; Barber, BE |
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| Journal | BMC MEDICINE |
| Pages | 563 |
| Volume | 22 |
| Date | 28/12/2024 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s12916-024-03787-0 |