Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) and chronic back, neck/shoulder & widespread pain can be explained by shared underlying genetic variants; and (ii) higher CRP levels causally contribute to these conditions.
| Authors | Farrell, SF; Sterling, M; Klyne, DM; Mustafa, S; Campos, AI; Kho, PF; Lundberg, M; Rentería, ME; Ngo, TT; Cuéllar-Partida, G |
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| Journal | EUROPEAN SPINE JOURNAL |
| Pages | 2078-2085 |
| Volume | 32 |
| Date | 17/05/2023 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1007/s00586-023-07711-7 |