Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This metastatic process is called perineural invasion (PNI) and spread (PNS). An in vivo sciatic nerve mouse model is used for cSCCHN PNI/PNS. Here we describe a complementary whisker pad model which allows for molecular studies investigating drivers of PNI/PNS in the head and neck environment.
| Authors | de Lima, PO; Broit, N; Huang, JD; Lim, JH; Gardiner, DJ; Brown, IS; Panizza, BJ; Boyle, GM; Simpson, F |
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| Journal | Frontiers In Oncology |
| Pages | |
| Volume | 13 |
| Date | 7/10/2023 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3389/fonc.2023.1231104 |