The Multi-Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre-Clinical Efficacy in Endometrial Cancer.

Abstract

Endometrial cancer is one of the few cancers for which mortality is still increasing. A lack of treatment options remains a major challenge, particularly for some subtypes of the disease. GZD824, also known as olverembatinib, is a multi-kinase inhibitor previously investigated in clinical trials for chronic myeloid leukaemia and Ph+ acute lymphoblastic leukaemia as a BCR-ABL inhibitor. This study aimed to investigate the pre-clinical efficacy of GZD824 for the treatment of EC.

Authors Liu, D; Glubb, D; O'Mara, T; Ford, CE
Journal Cancer medicine
Pages e70531
Volume 14
Date 1/01/2025
Grant ID APP1173170 | National Health and Medical Research Council; UNSW Med & Health ECAN seed grant
Funding Body
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1002/cam4.70531