QIMR Berghofer

Microglial ferroptotic stress causes non-cell autonomous neuronal death.

Abstract

Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing neuronal death in degenerative diseases of the central nervous system (CNS). The precise role for ferroptosis in causing neuronal death is yet to be fully resolved.

Authors Liddell, JR; Hilton, JBW; Kysenius, K; Billings, JL; Nikseresht, S; McInnes, LE; Hare, DJ; Paul, B; Mercer, SW; Belaidi, AA; Ayton, S; Roberts, BR; Beckman, JS; McLean, CA; White, AR; Donnelly, PS; Bush, AI; Crouch, PJ
Journal MOLECULAR NEURODEGENERATION
Pages 14
Volume 19
Date 5/03/2024
Grant ID
Funding Body
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s13024-023-00691-8