Abstract

T cells), and the heightened production of the pro-inflammatory cytokines TNF-a, IL-6, and IL-1ß. These phenotypes, as well as the increased mortality, were significantly attenuated following the administration of anti-TNF-a to PVM-infected, BW245c-treated mice. In summary, pharmacological activation of the DP1 receptor in PVM-infected neonatal mice boosts antiviral innate and adaptive immunity, however, this is ultimately detrimental, as a consequence of increased TNF-a-induced morbidity and mortality.

Authors	Ullah, Md Ashik; Rittchen, Sonja; Li, Jia; Hasnain, Sumaira Z; Phipps, Simon
Journal	Mucosal Immunology
Pages	963-972
Volume	14
Date	1/01/2021
Grant ID
Funding Body
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41385-021-00405-7