QIMR Berghofer

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines.

Abstract

T and NK cells were crucial to the vaccine-elicited tumor regression. Individualized autologous tumor antigen vaccines based on effective activation of the innate immune system by bacterial cytoplasmic membranes hold great potential for personalized treatment of postoperative patients with cancer.

Authors Chen, Long; Qin, Hao; Zhao, Ruifang; Zhao, Xiao; Lin, Liangru; Chen, Yang; Lin, Yixuan; Li, Yao; Qin, Yuting; Li, Yiye; Liu, Shaoli; Cheng, Keman; Chen, Hanqing; Shi, Jian; Anderson, Gregory J; Wu, Yan; Zhao, Yuliang; Nie, Guangjun
Journal Science Translational Medicine
Pages
Volume 13
Date 1/01/2021
Grant ID
Funding Body
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1126/scitranslmed.abc2816