Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
Abstract
T cell proliferation and inhibiting IL-2 and TNF production. We conclude that Acan1 and Nak1 warrant further development as therapeutics for the treatment of autoimmunity, particularly gastrointestinal inflammatory conditions.
| Authors | Smallwood, Taylor B; Navarro, Severine; Cristofori-Armstrong, Ben; Watkins, Thomas S; Tungatt, Katie; Ryan, Rachael Ym; Haigh, Oscar L; Lutzky, Viviana P; Mulvenna, Jason P; Rosengren, K Johan; Loukas, Alex; Miles, John J; Clark, Richard J |
|---|---|
| Journal | Journal of Biological Chemistry |
| Pages | 100834 |
| Volume | 297 |
| Date | 1/01/2021 |
| Grant ID | |
| Funding Body | |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.jbc.2021.100834 |