PURPOSE: may promote colorectal carcinogenesis through its suppressive effect on T-cell-mediated antitumor immunity, the specific T-cell subsets involved remain uncertain. EXPERIMENTAL DESIGN: and T-cell subsets. RESULTS: was not significantly associated with T-cell subset densities in tumor intraepithelial regions or with macrophage densities. CONCLUSIONS: is associated with lower densities of stromal memory helper T cells. Our findings provide evidence for the interactive pathogenic roles of microbiota and specific immune cells.
| Authors | Borowsky, Jennifer; Haruki, Koichiro; Lau, Mai Chan; Dias Costa, Andressa; Väyrynen, Juha P; Ugai, Tomotaka; Arima, Kota; da Silva, Annacarolina; Felt, Kristen; Zhao, Melissa; Gurjao, Carino; Twombly, Tyler S; Fujiyoshi, Kenji; Väyrynen, Sara A; Hamada, Tsuyoshi; Mima, Kosuke; Bullman, Susan; Harrison, Tabitha A; Phipps, Amanda I; Peters, Ulrike; Ng, Kimmie; Meyerhardt, Jeffrey A; Song, Mingyang; Giovannucci, Edward L; Wu, Kana; Zhang, Xuehong; Freeman, Gordon J; Huttenhower, Curtis; Garrett, Wendy S; Chan, Andrew T; Leggett, Barbara A; Whitehall, Vicki Lj; Walker, Neal; Brown, Ian; Bettington, Mark; Nishihara, Reiko; Fuchs, Charles S; Lennerz, Jochen K; Giannakis, Marios; Nowak, Jonathan A; Ogino, Shuji |
|---|---|
| Journal | CLINICAL CANCER RESEARCH |
| Pages | 2816-2826 |
| Volume | 27 |
| Date | 1/01/2021 |
| Grant ID | |
| Funding Body | |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1158/1078-0432.CCR-20-4009 |