Abstract

expression profile switch to a predominantly invasive phenotype, the mechanisms by which this switch is propagated and promotes invasion remain poorly defined. We have found that a reciprocal relationship between BRN2 and NOTCH1/2 signaling exists in melanoma cells in vitro, within patient datasets and in vivo primary and metastatic human tumors that bolsters acquisition of invasiveness. Working through the epigenetic modulator EZH2, the BRN2-NOTCH1/2 axis is potentially a key mechanism by which the invasive phenotype is maintained. Given the emergence of agents targeting both EZH2 and NOTCH, understanding the mechanism through which BRN2 promotes heterogeneity may provide crucial biomarkers to predict treatment response to prevent metastasis.

Authors	Fane, Mitchell E; Chhabra, Yash; Spoerri, Loredana; Simmons, Jacinta L; Ludwig, Raquelle; Bonvin, Elise; Goding, Colin R; Sturm, Richard A; Boyle, Glen M; Haass, Nikolas K; Piper, Michael; Smith, Aaron G
Journal	Journal of Investigative Dermatology
Pages	1845-1857
Volume	142
Date	1/01/2021
Grant ID
Funding Body
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.jid.2020.12.039