, was not substantially altered in response to CHIKV. The upregulation of Toll, IMD and JAK-STAT pathways was only observed at 28°C. Functional annotations suggested that genes in immune response and metabolic pathways related to energy supply and DNA replication were involved in temperature-dependent changes. Time post infection also led to substantially different gene expression profiles, and this varied with temperature. In conclusion, temperature significantly modulates mosquito gene expression in response to infection, potentially leading to impairment of immune defences at higher temperatures.
| Authors | Wimalasiri-Yapa, B M C Randika; Barrero, Roberto A; Stassen, Liesel; Hafner, Louise M; McGraw, Elizabeth A; Pyke, Alyssa T; Jansen, Cassie C; Suhrbier, Andreas; Yakob, Laith; Hu, Wenbiao; Devine, Gregor J; Frentiu, Francesca D |
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| Journal | OPEN BIOLOGY |
| Pages | 200246 |
| Volume | 11 |
| Date | 1/01/2021 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1098/rsob.200246 |