Abstract

PURPOSE: To evaluate the association between a polygenic risk score (PRS) for Primary Open Angle Glaucoma (POAG) and the age of first trabeculectomy and the need for bilateral trabeculectomy. DESIGN: percentile) and bottom decile. RESULTS: A higher PRS was associated with a younger age at first trabeculectomy (beta: -1.94 years/SD 95% CI: [-0.41, -3.47] P=0.014). Participants in the top decile underwent their first trabeculectomy approximately 7 years earlier than participants in the lowest decile (mean difference: -7.04 years [2.82, 11.26]). Participants in the top decile were 1.41 fold more likely to require bilateral trabeculectomy than participants in the bottom decile (OR: 1.41 [1.06, 1.91] P=0.021). CONCLUSIONS: This report identified clinically relevant correlations between glaucoma PRS and need for surgical intervention in glaucoma. Further work is required to investigate the association between PRS and other clinical endpoints, such as treatment initiation.

Authors	Marshall, Henry N; Hollitt, Georgina L; Wilckens, Kristopher; Mullany, Sean; Kuruvilla, Shilpa; Souzeau, Emmanuelle; Landers, John; Han, Xikun; MacGregor, Stuart; Craig, Jamie E; Siggs, Owen M
Journal	Ophthalmology. Glaucoma
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Date	1/01/2022
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URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.ogla.2022.06.009