IFN-? Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis.
Abstract
mice. In contrast, inhibition of ROS production decreased NET formation, cellular inflammation, and mucus hypersecretion. These data suggest that IFN-? signaling in neutrophils dampens ROS-induced NETosis, limiting the magnitude of the inflammatory response and mucus production. Therapeutics that promote IFN-? signaling may confer protection against sLRI.
| Authors | Sebina, Ismail; Rashid, Ridwan B; Sikder, Md Al Amin; Rahman, Muhammed Mahfuzur; Ahmed, Tufael; Radford-Smith, Daniel E; Kotenko, Sergei V; Hill, Geoffrey R; Bald, Tobias; Phipps, Simon |
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| Journal | Journal of immunology (Baltimore, Md. : 1950) |
| Pages | 2806-2816 |
| Volume | 208 |
| Date | 1/01/2022 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.4049/jimmunol.2100876 |