Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment.
Abstract
independently associated with poor prognosis in glioblastoma patients. Finally, we observed a substantial upregulation of DDR genes after treatment with TMZ and/or RT, particularly in RT-treated glioblastoma cells, peaking within 24 h after treatment. Our results confirm the potential influence of DDR genes in patient outcome. The observation of DDR genes in response to TMZ and RT gives insight into the global response of DDR pathways after adjuvant treatment in glioblastoma, which may have utility in determining DDR targets for inhibition.
| Authors | Lozinski, Mathew; Bowden, Nikola A; Graves, Moira C; Fay, Michael; Day, Bryan W; Stringer, Brett W; Tooney, Paul A |
|---|---|
| Journal | CELLS |
| Pages | |
| Volume | 11 |
| Date | 1/01/2022 |
| Grant ID | |
| Funding Body | |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/cells11071215 |