Abstract

Background Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. Methods Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. Results During the mean follow-up of 6.34 years (SD=4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among ovarian cancer patients overall or by histotype. Conclusions This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. Impact Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

Authors	Phung, Minh Tung; Alimujiang, Aliya; Berchuck, Andrew; Anton-Cluver, Hoda; Schildkraut, Joellen M; Bandera, Elisa V; Chang-Claude, Jenny; Chase, Anne; Doherty, Jennifer Anne; Grout, Bronwyn; Goodman, Marc T; Hanley, Gillian E; Lee, Alice W; McKinnon Deurloo, Cindy; Menon, Usha; Modugno, Francesmary; Pharoah, Paul D P; Pike, Malcolm C; Richardson, Jean; Risch, Harvey A; Sieh, Weiva; Terry, Kathryn L; Webb, Penelope M; Wentzensen, Nicolas; Wu, Anna H; Pearce, Celeste Leigh
Journal	Cancer Epidemiology Biomarkers and Prevention
Pages	909-913
Volume	31
Date	1/01/2022
Grant ID
Funding Body
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1158/1055-9965.EPI-21-1091