Association of High Polygenic Risk With Visual Field Worsening Despite Treatment in Early Primary Open-Angle Glaucoma
Abstract
IMPORTANCE Irreversible vision loss from primary open-angle glaucoma (POAG) can be prevented through timely diagnosis and treatment, although definitive diagnosis can be difficult in early-stage disease. As a consequence, large numbers of individuals with suspected glaucoma require regular monitoring, even though many of these may never develop disease and other high-risk individuals with suspected glaucoma may have delayed or inadequate treatment. POAG is one of the most heritable common diseases, and this provides an opportunity to use genetic instruments in risk-stratified screening, diagnosis, and treatment of early glaucoma.
| Authors | Siggs, Owen M. M.; Qassim, Ayub; Han, Xikun; Marshall, Henry N. N.; Mullany, Sean; He, Weixiong; Souzeau, Emmanuelle; Galanopoulos, Anna; Agar, Ashish; Landers, John; Casson, Robert J. J.; Hewitt, Alex W. W.; Healey, Paul R. R.; Graham, Stuart L. L.; MacGregor, Stuart; Craig, Jamie E. E. |
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| Journal | JAMA ophthalmology |
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| Date | 1/01/2022 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1001/jamaophthalmol.2022.4688 |