Abstract

BACKGROUND: Liver diseases are important contributors to the mortality gap between Indigenous and non-Indigenous Australians. AIMS: This cohort study examined factors associated with hospital admissions and healthcare outcomes among Indigenous Australians with cirrhosis. METHODS: Patient-reported outcomes were obtained by face-to-face interview (CLDQ and SF-36). Clinical data were extracted from medical records and through data linkage for 534 patients (25 Indigenous). Cumulative overall survival (Kaplan-Meier), rates of hospital admissions and emergency presentations, and costs were assessed by Indigenous status. Incidence rate ratios (IRR; Poisson regression) were reported. RESULTS: Indigenous Australians admitted to hospital with cirrhosis had lower educational status compared to non-Indigenous patients (79.2% vs. 43.4%; p<0.001). The two groups had, in general, similar clinical characteristics including disease severity (p=0.78), presence of cirrhosis complications (p=0.67), comorbidities (p=0.62), rates of cirrhosis-related admissions (p=0.86), and 5-year survival (p=0.30). However, Indigenous patients had a lower score in the SF-36 domain related to bodily pain (p=0.037), more cirrhosis admissions via the emergency department (IRR=1.42, 95%CI 1.10-1.83) and fewer planned cirrhosis admissions (IRR=0.32, 95%CI 0.14-0.72). The total cost for cirrhosis-related hospital admissions for 534 patients over six years (Jul-2012 to Jun-2018) was $13.7 million. The cost of cirrhosis-related hospital admissions was double for Indigenous patients (cost ratio=2.04, 95%CI 2.04-2.05). CONCLUSIONS: Our data highlight the disparities in health service use and patient-reported outcomes, despite having similar clinical profiles. Integration between primary care, Aboriginal Community Controlled Health Organisations and liver specialists is critical for appropriate health service delivery and effective use of resources. Chronic liver disease costs the community dearly. This article is protected by copyright. All rights reserved.

Authors	Amarasena, Samath; Clark, Paul J; Gordon, Louisa G; Toombs, Maree; Pratt, Greg; Hartel, Gunter; Bernardes, Christina M; Powell, Elizabeth E; Valery, Patricia C
Journal	INTERNAL MEDICINE JOURNAL
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Date	1/01/2022
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URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1111/imj.15854