Selective Targeting of Protein Kinase C (PKC)-? Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8+ T Cells in Immunotherapy-Resistant and Metastatic Cancers.
Abstract
T cells. Disrupting nPKC-? but retaining its cytoplasmic function may offer a means to target metastases in combination with chemotherapy or immunotherapy.
| Authors | Dunn, Jenny; McCuaig, Robert D; Tan, Abel H Y; Tu, Wen Juan; Wu, Fan; Wagstaff, Kylie M; Zafar, Anjum; Ali, Sayed; Diwakar, Himanshu; Dahlstrom, Jane E; Bean, Elaine G; Forwood, Jade K; Tsimbalyuk, Sofiya; Cross, Emily M; Hardy, Kristine; Bain, Amanda L; Ahern, Elizabeth; Dolcetti, Riccardo; Mazzieri, Roberta; Yip, Desmond; Eastgate, Melissa; Malik, Laeeq; Milburn, Peter; Jans, David A; Rao, Sudha |
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| Journal | Cancers |
| Pages | |
| Volume | 14 |
| Date | 1/01/2022 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3390/cancers14061596 |