Abstract

Background and Aims: Ulcerative colitis [UC] is a major form of inflammatory bowel disease globally. Phenotypic heterogeneity is defined by several variables including age of onset and disease extent. The genetics of disease severity remains poorly understood. To further investigate this, we performed a genome wide association [GWA] study using an extremes of phenotype strategy.

Authors	Mortlock, Sally; Lord, Anton; Montgomery, Grant; Zakrzewski, Martha; Simms, Lisa A.; Krishnaprasad, Krupa; Hanigan, Katherine; Doecke, James D.; Walsh, Alissa; Lawrance, Ian C.; Bampton, Peter A.; Andrews, Jane M.; Mahy, Gillian; Connor, Susan J.; Sparrow, Miles P.; Bell, Sally; Florin, Timothy H.; Begun, Jakob; Gearry, Richard B.; Radford-Smith, Graham L.
Journal	Journal of Crohns & Colitis
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Date	1/01/2022
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URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1093/ecco-jcc/jjac121