cells were preferentially detected along the outer border of the portal tracts, and also in the portal interstitium adjacent to the portal vein, bile duct, lymphatic vessels and hepatic artery. cDC1s abounded along the lymphatic vessels, while cDC2s mostly surrounded the biliary tree. The specific distributions of these discrete subsets predict that they may serve distinct functions in this compartment. Overall, our findings suggest that portal tracts and their embedded cellular networks of myeloid cells form a distinctive lymphoid compartment in the liver that has the potential to orchestrate immune responses in this organ.
| Authors | English, Kieran; Tan, Sioh Yang; Kwan, Rain; Holz, Lauren E; Sierro, Frederic; McGuffog, Claire; Kaisho, Tsuneyasu; Heath, William R; MacDonald, Kelli Pa; McCaughan, Geoffrey W; Bowen, David G; Bertolino, Patrick |
|---|---|
| Journal | IMMUNOLOGY AND CELL BIOLOGY |
| Pages | 394-408 |
| Volume | 100 |
| Date | 1/01/2022 |
| Grant ID | |
| Funding Body | |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1111/imcb.12559 |