QIMR Berghofer

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.

Abstract

T cell responses in mice and humans. Thus, manipulation of type I IFN signaling is a promising strategy for improving disease outcome in VL patients.

Authors Kumar, Rajiv; Bunn, Patrick T; Singh, Siddharth Sankar; Ng, Susanna S; Montes de Oca, Marcela; De Labastida Rivera, Fabian; Chauhan, Shashi Bhushan; Singh, Neetu; Faleiro, Rebecca J; Edwards, Chelsea L; Frame, Teija C M; Sheel, Meru; Austin, Rebecca J; Lane, Steven W; Bald, Tobias; Smyth, Mark J; Hill, Geoffrey R; Best, Shannon E; Haque, Ashraful; Corvino, Dillon; Waddell, Nic; Koufariotis, Lambross; Mukhopadhay, Pamela; Rai, Madhukar; Chakravarty, Jaya; Singh, Om Prakash; Sacks, David; Nylen, Susanne; Uzonna, Jude; Sundar, Shyam; Engwerda, Christian R
Journal Cell Reports
Pages 2512-2525.e9
Volume 30
Date 1/02/2020
Grant ID U19 AI074321
Funding Body NIH Tropical Medicine Research Centers (TMRC) grant
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.celrep.2020.01.099
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