, OR?=?3.8). We further investigate the genetic architecture of miscarriage with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses. Our results show that miscarriage etiopathogenesis is partly driven by genetic variation potentially related to placental biology, and illustrate the utility of large-scale biobank data for understanding this pregnancy complication.
Authors | Laisk, Triin; Soares, Ana Luiza G; Ferreira, Teresa; Painter, Jodie N; Censin, Jenny C; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lin, Kuang; Liu, Siyang; Millwood, Iona Y; Ramu, Avinash; Southcombe, Jennifer; Andersen, Marianne S; Yang, Ling; Becker, Christian M; Børglum, Anders D; Gordon, Scott D; Bybjerg-Grauholm, Jonas; Helgeland, Øyvind; Hougaard, David M; Jin, Xin; Johansson, Stefan; Juodakis, Julius; Kartsonaki, Christiana; Kukushkina, Viktorija; Lind, Penelope A; Metspalu, Andres; Montgomery, Grant W; Morris, Andrew P; Mors, Ole; Mortensen, Preben B; Njølstad, Pål R; Nordentoft, Merete; Nyholt, Dale R; Lippincott, Margaret; Seminara, Stephanie; Salumets, Andres; Snieder, Harold; Zondervan, Krina; Werge, Thomas; Chen, Zhengming; Conrad, Donald F; Jacobsson, Bo; Li, Liming; Martin, Nicholas G; Neale, Benjamin M; Nielsen, Rasmus; Walters, Robin G; Granne, Ingrid; Medland, Sarah E; Mägi, Reedik; Lawlor, Deborah A; Lindgren, Cecilia M |
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Journal | Nature Communications |
Pages | 5980 |
Volume | 11 |
Date | 1/11/2020 |
Grant ID | |
Funding Body | Department of Health |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41467-020-19742-5 |
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