QIMR Berghofer

The genetic architecture of sporadic and multiple consecutive miscarriage.

Abstract

, OR?=?3.8). We further investigate the genetic architecture of miscarriage with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses. Our results show that miscarriage etiopathogenesis is partly driven by genetic variation potentially related to placental biology, and illustrate the utility of large-scale biobank data for understanding this pregnancy complication.

Authors Laisk, Triin; Soares, Ana Luiza G; Ferreira, Teresa; Painter, Jodie N; Censin, Jenny C; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lin, Kuang; Liu, Siyang; Millwood, Iona Y; Ramu, Avinash; Southcombe, Jennifer; Andersen, Marianne S; Yang, Ling; Becker, Christian M; Børglum, Anders D; Gordon, Scott D; Bybjerg-Grauholm, Jonas; Helgeland, Øyvind; Hougaard, David M; Jin, Xin; Johansson, Stefan; Juodakis, Julius; Kartsonaki, Christiana; Kukushkina, Viktorija; Lind, Penelope A; Metspalu, Andres; Montgomery, Grant W; Morris, Andrew P; Mors, Ole; Mortensen, Preben B; Njølstad, Pål R; Nordentoft, Merete; Nyholt, Dale R; Lippincott, Margaret; Seminara, Stephanie; Salumets, Andres; Snieder, Harold; Zondervan, Krina; Werge, Thomas; Chen, Zhengming; Conrad, Donald F; Jacobsson, Bo; Li, Liming; Martin, Nicholas G; Neale, Benjamin M; Nielsen, Rasmus; Walters, Robin G; Granne, Ingrid; Medland, Sarah E; Mägi, Reedik; Lawlor, Deborah A; Lindgren, Cecilia M
Journal Nature Communications
Pages 5980
Volume 11
Date 1/11/2020
Grant ID
Funding Body Department of Health
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41467-020-19742-5
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