T cells. Pharmacological inhibition of A2AR overcame the adenosine-mediated negative regulation of ADCP by rituximab in a xeno-transplanted lymphoma model. Moreover, aberrant overexpression of CD39, an apical ecto-enzyme for adenosine generation, showed a negative impact on prognosis in patients with diffuse large B-cell lymphoma, as well as on preclinical efficacy of rituximab. Together, adenosine acts as a "don't eat me signal", and may be a potential target to harness anti-lymphoma immunity.
| Authors | Nakamura, Kyohei; Casey, Mika; Oey, Harald; Vari, Frank; Stagg, John; Gandhi, Maher K; Smyth, Mark J |
|---|---|
| Journal | LEUKEMIA |
| Pages | 2708-2721 |
| Volume | 34 |
| Date | 1/04/2020 |
| Grant ID | 1159593 |
| Funding Body | Department of Health | National Health and Medical Research Council (NHMRC) |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41375-020-0811-3 |
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