Systemic administration of IL-33 induces a population of circulating KLRG1hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma.

Abstract

ILC2s and inhibits type 1 immunity against multiple myeloma. These results argue against therapeutic administration of IL-33 to myeloma patients.

Authors Guillerey, Camille; Stannard, Kimberley; Chen, Jason; Krumeich, Sophie; Miles, Kim; Nakamura, Kyohei; Smith, Jessica; Yu, Yuan; Ng, Susanna; Harjunpää, Heidi; Teng, Michele W L; Engwerda, Christian; Belz, Gabrielle T; Smyth, Mark J
Journal IMMUNOLOGY AND CELL BIOLOGY
Pages 65-83
Volume 99
Date 1/08/2020
Grant ID 1122183
Funding Body Cancer Australia
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1111/imcb.12390
Download Article