QIMR Berghofer

RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.

Abstract

NONO is an RBP upstream regulator of both STAT3 RNA and protein levels and function. It represents an important and clinically relevant promoter of growth and resistance of TNBCs. NONO is also therefore a potential therapeutic target in TNBC.

Authors Kim, Seong-Jin; Ju, Jin-Sung; Kang, Myoung-Hee; Eun, Ji Won; Kim, Young Ha; Raninga, Prahlad V; Khanna, Kum Kum; Gyorffy, Balázs; Pack, Chan-Gi; Han, Hee-Dong; Lee, Hee Jin; Gong, Gyungyub; Shin, Yong; Mills, Gordon B; Eyun, Seong-Il; Park, Yun-Yong
Journal THERANOSTICS
Pages 7974-7992
Volume 10
Date 1/07/2020
Grant ID HI17C0380
Funding Body Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.7150/thno.45037