NONO is an RBP upstream regulator of both STAT3 RNA and protein levels and function. It represents an important and clinically relevant promoter of growth and resistance of TNBCs. NONO is also therefore a potential therapeutic target in TNBC.
Authors | Kim, Seong-Jin; Ju, Jin-Sung; Kang, Myoung-Hee; Eun, Ji Won; Kim, Young Ha; Raninga, Prahlad V; Khanna, Kum Kum; Gyorffy, Balázs; Pack, Chan-Gi; Han, Hee-Dong; Lee, Hee Jin; Gong, Gyungyub; Shin, Yong; Mills, Gordon B; Eyun, Seong-Il; Park, Yun-Yong |
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Journal | THERANOSTICS |
Pages | 7974-7992 |
Volume | 10 |
Date | 1/07/2020 |
Grant ID | HI17C0380 |
Funding Body | Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea |
URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.7150/thno.45037 |