Natural Killers out of Thin Air.
Abstract
The regulatory mechanisms controlling natural killer (NK) cells in the tumor microenvironment remain unknown. In this issue, Ni. et al. provide evidence that the transcription factor HIF-1a acts as a key negative regulator of NK cell metabolic fitness in the tumor microenvironment that critically impedes NK cell anti-tumor immune responses.
| Authors | Nakamura, Kyohei; Smyth, Mark J |
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| Journal | IMMUNITY |
| Pages | 895-897 |
| Volume | 52 |
| Date | 1/06/2020 |
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| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.immuni.2020.05.007 |
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