Abstract

making this pathway a promising candidate for targeted therapy. In conclusion, we observe enrichment of mutation signature 4 in ESCC tumors from patients with a history of tobacco chewing. This is likely due to direct exposure of esophagus to tobacco carcinogens when it is chewed and swallowed. Genomic alterations were frequently observed in PIK3CA-AKT pathway members independent of the history of tobacco usage. PIK3CA pathway can be potentially targeted in ESCC which currently has no effective targeted therapeutic options.

Authors	Mangalaparthi, Kiran K; Patel, Krishna; Khan, Aafaque A; Manoharan, Malini; Karunakaran, Coral; Murugan, Sakthivel; Gupta, Ravi; Gupta, Rohit; Khanna-Gupta, Arati; Chaudhuri, Amitabha; Kumar, Prashant; Nair, Bipin; Kumar, Rekha V; Prasad, T S Keshava; Chatterjee, Aditi; Pandey, Akhilesh; Gowda, Harsha
Journal	Frontiers In Oncology
Pages	1457
Volume	10
Date	1/08/2020
Grant ID	IA/M/15/1/502023
Funding Body	Wellcome Trust/DBT India Alliance Margdarshi Fellowship
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.3389/fonc.2020.01457