QIMR Berghofer

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.

Abstract

). This glaucoma PRS will facilitate the development of a personalized approach for earlier treatment of high-risk individuals, with less intensive monitoring and treatment being possible for lower-risk groups.

Authors Craig, Jamie E; Han, Xikun; Qassim, Ayub; Hassall, Mark; Cooke Bailey, Jessica N; Kinzy, Tyler G; Khawaja, Anthony P; An, Jiyuan; Marshall, Henry; Gharahkhani, Puya; Igo, Robert P; Graham, Stuart L; Healey, Paul R; Ong, Jue-Sheng; Zhou, Tiger; Siggs, Owen; Law, Matthew H; Souzeau, Emmanuelle; Ridge, Bronwyn; Hysi, Pirro G; Burdon, Kathryn P; Mills, Richard A; Landers, John; Ruddle, Jonathan B; Agar, Ashish; Galanopoulos, Anna; White, Andrew J R; Willoughby, Colin E; Andrew, Nicholas H; Best, Stephen; Vincent, Andrea L; Goldberg, Ivan; Radford-Smith, Graham; Martin, Nicholas G; Montgomery, Grant W; Vitart, Veronique; Hoehn, Rene; Wojciechowski, Robert; Jonas, Jost B; Aung, Tin; Pasquale, Louis R; Cree, Angela Jane; Sivaprasad, Sobha; Vallabh, Neeru A; , ; , ; Viswanathan, Ananth C; Pasutto, Francesca; Haines, Jonathan L; Klaver, Caroline C W; van Duijn, Cornelia M; Casson, Robert J; Foster, Paul J; Khaw, Peng Tee; Hammond, Christopher J; Mackey, David A; Mitchell, Paul; Lotery, Andrew J; Wiggs, Janey L; Hewitt, Alex W; MacGregor, Stuart
Journal NATURE GENETICS
Pages 160-166
Volume 52
Date 1/01/2020
Grant ID R21 EY028671
Funding Body NEI NIH HHS
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1038/s41588-019-0556-y