Abstract

The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.

Authors	Korhonen, Pasi K; Gasser, Robin B; Ma, Guangxu; Wang, Tao; Stroehlein, Andreas J; Young, Neil D; Ang, Ching-Seng; Fernando, Deepani D; Lu, Hieng C; Taylor, Sara; Reynolds, Simone L; Mofiz, Ehtesham; Najaraj, Shivashankar H; Gowda, Harsha; Madugundu, Anil; Renuse, Santosh; Holt, Deborah; Pandey, Akhilesh; Papenfuss, Anthony T; Fischer, Katja
Journal	PLOS NEGLECTED TROPICAL DISEASES
Pages	e0008720
Volume	14
Date	1/10/2020
Grant ID
Funding Body	Australian Research Council (ARC) of Australia
URL	http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1371/journal.pntd.0008720