Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory.
Abstract
?=?0.006 and 0.016 respectively, p?<?0.001) but not average thickness. At the regional level, we identified seven cortical regions-in the frontal and temporal lobes-that showed variation in surface area and average cortical thickness over-and-above the global effect. These regions have been robustly implicated in language, memory, visual recognition and cognitive processing. Additionally, we demonstrate that these identified brain regions partly mediate the association between EA-PGS and cognitive test performance. Altogether, these findings advance our understanding of the neurobiology that underpins educational attainment and cognitive ability, providing focus points for future research.
| Authors | Mitchell, Brittany L; Cuéllar-Partida, Gabriel; Grasby, Katrina L; Campos, Adrian I; Strike, Lachlan T; Hwang, Liang-Dar; Okbay, Aysu; Thompson, Paul M; Medland, Sarah E; Martin, Nicholas G; Wright, Margaret J; Rentería, Miguel E |
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| Journal | NEUROIMAGE |
| Pages | 116691 |
| Volume | 212 |
| Date | 1/02/2020 |
| Grant ID | |
| Funding Body | Queensland University of Technology through a QUT Postgraduate Research Scholarship |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016/j.neuroimage.2020.116691 |
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